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   Articles with "cgas" as a keyword



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Activation of cGAS‐STING by Lethal Malaria N67C Dictates Immunity and Mortality through Induction of CD11b+Ly6Chi Proinflammatory Monocytes

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recommendations! Published in 2022 at "Advanced Science"

DOI: 10.1002/advs.202103701

Abstract: Cyclic GMP‐AMP synthase (cGAS) and stimulator of interferon genes (STING) play critical roles in the innate immunity against infectious diseases and are required to link pathogen DNA sensing to immune responses. However, the mechanisms by… read more here.

Keywords: cd11b ly6chi; lethal malaria; cgas sting; proinflammatory monocytes ... See more keywords
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Lipotoxicity-induced mtDNA release promotes diabetic cardiomyopathy by activating the cGAS-STING pathway in obesity-related diabetes.

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recommendations! Published in 2022 at "Cell biology and toxicology"

DOI: 10.1007/s10565-021-09692-z

Abstract: Diabetic cardiomyopathy (DCM) is characterized by lipid accumulation, mitochondrial dysfunction, and aseptic inflammatory activation. Mitochondria-derived cytosolic DNA has been reported to induce inflammation by activating cyclic GMP-AMP synthase (cGAS)/the stimulator of interferon genes (STING) pathway… read more here.

Keywords: cgas; diabetic cardiomyopathy; dcm; cgas sting ... See more keywords
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TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

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recommendations! Published in 2020 at "Cell"

DOI: 10.1016/j.cell.2020.09.020

Abstract: Summary Cytoplasmic accumulation of TDP-43 is a disease hallmark for many cases of amyotrophic lateral sclerosis (ALS), associated with a neuroinflammatory cytokine profile related to upregulation of nuclear factor κB (NF-κB) and type I interferon… read more here.

Keywords: cgas; tdp triggers; dna; triggers mitochondrial ... See more keywords
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Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury.

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recommendations! Published in 2019 at "Cell reports"

DOI: 10.1016/j.celrep.2019.09.050

Abstract: Acute kidney injury (AKI) is characterized by mitochondrial dysfunction and activation of the innate immune system. The cyclic GMP-AMP synthase (cGAS) stimulator of interferon genes (STING) pathway detects cytosolic DNA and induces innate immunity. Here,… read more here.

Keywords: kidney injury; cgas sting; cgas; activation ... See more keywords
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Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS.

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recommendations! Published in 2018 at "Cell systems"

DOI: 10.1016/j.cels.2018.10.010

Abstract: Viral DNA sensing is an essential component of the mammalian innate immune response. Upon binding viral DNA, the cyclic-GMP-AMP synthase (cGAS) catalyzes the production of cyclic dinucleotides to induce type I interferons. However, little is… read more here.

Keywords: dynamics uncover; cgas; interactome proteome; uncover immune ... See more keywords
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The spatial organization of cGAS-TREX1 interactions.

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recommendations! Published in 2021 at "Developmental cell"

DOI: 10.1016/j.devcel.2021.03.016

Abstract: Coupling DNA sensing to the initiation of immune responses necessitates auxiliary control mechanisms to avoid autoimmunity. A key factor is the exonuclease TREX1, which antagonizes DNA-mediated activation of cGAS. Two studies, by Mohr et al. (2021)… read more here.

Keywords: spatial organization; cgas; trex1; trex1 interactions ... See more keywords
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Bioactive modulators targeting STING adaptor in cGAS-STING pathway.

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recommendations! Published in 2019 at "Drug discovery today"

DOI: 10.1016/j.drudis.2019.11.007

Abstract: The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING)-pathway triggers innate immune responses by recognizing cytosolic DNA. Recent studies revealed that STING adaptor associates with various diseases, and several modulators targeting STING have been identified… read more here.

Keywords: cgas; sting pathway; targeting sting; sting adaptor ... See more keywords
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cGAS-STING and Cancer: Dichotomous Roles in Tumor Immunity and Development.

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recommendations! Published in 2018 at "Trends in immunology"

DOI: 10.1016/j.it.2017.07.013

Abstract: cGMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) sensing has emerged as a key regulator of innate immune responses to both exogenous and endogenous DNA. Recent studies reveal critical roles for this pathway in natural antitumor… read more here.

Keywords: cgas; immunity; sting cancer; cgas sting ... See more keywords
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Mathematical modeling of the cGAS pathway reveals robustness of DNA sensing to TREX1 feedback.

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recommendations! Published in 2019 at "Journal of theoretical biology"

DOI: 10.1016/j.jtbi.2018.11.001

Abstract: Cyclic GMP-AMP synthase (cGAS) has recently been identified as the primary protein that detects cytosolic double stranded DNA to invoke a type I interferon response. The cGAS pathway is vital in the recognition of DNA… read more here.

Keywords: cgas pathway; cgas; dna; model ... See more keywords
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Translation stress and collided ribosomes are co-activators of cGAS

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recommendations! Published in 2021 at "Molecular Cell"

DOI: 10.1016/j.molcel.2021.05.018

Abstract: Summary The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway senses cytosolic DNA and induces interferon-stimulated genes (ISGs) to activate the innate immune system. Here, we report the unexpected discovery that cGAS also senses dysfunctional… read more here.

Keywords: cgas; translation stress; stress collided; translation ... See more keywords
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cGAS and CD-NTase enzymes: structure, mechanism, and evolution

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recommendations! Published in 2019 at "Current Opinion in Structural Biology"

DOI: 10.1016/j.sbi.2019.08.003

Abstract: Cyclic GMP–AMP synthase (cGAS) is a signaling enzyme in human cells that controls immune-sensing of cytosolic DNA. The recent discoveries of diverse structural homologs of cGAS in animals and bacteria reveal that cGAS-like signaling is… read more here.

Keywords: cgas; structure mechanism; enzymes structure; biology ... See more keywords