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   Articles with "cgas" as a keyword



Mitochondrion‐Targeted Type I Photodynamic Therapy for Agonist Independent cGAS‐STING Activation

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recommendations! Published in 2025 at "Advanced Materials"

DOI: 10.1002/adma.202418894

Abstract: CGAS‐STING agonists generally lead to hyperimmunity and systemic toxicity, hindering their immunotherapeutic outcomes. Herein, a mitochondrion‐targeted nanoagonist (termed HABH) containing boron dipyrromethene (BODIPY)‐derived type I photosensitizer (BDP) and Au nanoparticle‐engineered hollow mesoporous silica (HMSN/AuNPs) has… read more here.

Keywords: cgas; agonist independent; mitochondrion targeted; independent cgas ... See more keywords

Activation of cGAS‐STING by Lethal Malaria N67C Dictates Immunity and Mortality through Induction of CD11b+Ly6Chi Proinflammatory Monocytes

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recommendations! Published in 2022 at "Advanced Science"

DOI: 10.1002/advs.202103701

Abstract: Cyclic GMP‐AMP synthase (cGAS) and stimulator of interferon genes (STING) play critical roles in the innate immunity against infectious diseases and are required to link pathogen DNA sensing to immune responses. However, the mechanisms by… read more here.

Keywords: cd11b ly6chi; lethal malaria; cgas sting; proinflammatory monocytes ... See more keywords

Tumor Exosomal ENPP1 Hydrolyzes cGAMP to Inhibit cGAS‐STING Signaling

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202308131

Abstract: To evade immune surveillance, tumor cells express ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) on the surface of their membrane, which degrades extracellular cyclic GMP‐AMP (cGAMP), thereby inhibiting the cyclic GMP‐AMP synthase (cGAS) stimulator of interferon gene… read more here.

Keywords: cgas; tumor; cgamp; exosomal enpp1 ... See more keywords

Microglial cGAS Deletion Preserves Intercellular Communication and Alleviates Amyloid‐β‐Induced Pathogenesis of Alzheimer's Disease

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recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202410910

Abstract: Innate immune activation plays a crucial role in the pathogenesis of Alzheimer's disease (AD) and related dementias (ADRD). The cytosolic DNA sensing pathway, involving cGAMP synthase (cGAS) and Stimulator of Interferon Genes (STING), has emerged… read more here.

Keywords: pathogenesis alzheimer; alzheimer disease; cgas; microglial cgas ... See more keywords

Gigaxonin Potentiates Antiviral Innate Immune Responses by Targeting cGAS and TREX1

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recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202507146

Abstract: Innate immunity is the first line of defense against viral infections. Cyclic GMP‐AMP synthase (cGAS) senses abnormal cytosolic double‐stranded DNA (dsDNA) and triggers the production of interferon and proinflammatory cytokines to eliminate viruses, whereas three‐prime… read more here.

Keywords: cgas; trex1; gigaxonin; antiviral innate ... See more keywords

BK Polyomavirus Infection of Bladder Microvascular Endothelial Cells Leads to the Activation of the cGAS‐STING Pathway

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recommendations! Published in 2024 at "Journal of Medical Virology"

DOI: 10.1002/jmv.70038

Abstract: BK polyomavirus (BKPyV) infection in humans is usually asymptomatic but ultimately results in viral persistence. In immunocompromised hosts, virus reactivation can lead to nephropathy or hemorrhagic cystitis. The urinary tract serves as a silent reservoir… read more here.

Keywords: cgas; microvascular endothelial; activation; infection ... See more keywords

Lipotoxicity-induced mtDNA release promotes diabetic cardiomyopathy by activating the cGAS-STING pathway in obesity-related diabetes.

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recommendations! Published in 2022 at "Cell biology and toxicology"

DOI: 10.1007/s10565-021-09692-z

Abstract: Diabetic cardiomyopathy (DCM) is characterized by lipid accumulation, mitochondrial dysfunction, and aseptic inflammatory activation. Mitochondria-derived cytosolic DNA has been reported to induce inflammation by activating cyclic GMP-AMP synthase (cGAS)/the stimulator of interferon genes (STING) pathway… read more here.

Keywords: cgas; diabetic cardiomyopathy; dcm; cgas sting ... See more keywords

TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

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recommendations! Published in 2020 at "Cell"

DOI: 10.1016/j.cell.2020.09.020

Abstract: Summary Cytoplasmic accumulation of TDP-43 is a disease hallmark for many cases of amyotrophic lateral sclerosis (ALS), associated with a neuroinflammatory cytokine profile related to upregulation of nuclear factor κB (NF-κB) and type I interferon… read more here.

Keywords: cgas; tdp triggers; dna; triggers mitochondrial ... See more keywords

Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury.

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recommendations! Published in 2019 at "Cell reports"

DOI: 10.1016/j.celrep.2019.09.050

Abstract: Acute kidney injury (AKI) is characterized by mitochondrial dysfunction and activation of the innate immune system. The cyclic GMP-AMP synthase (cGAS) stimulator of interferon genes (STING) pathway detects cytosolic DNA and induces innate immunity. Here,… read more here.

Keywords: kidney injury; cgas sting; cgas; activation ... See more keywords
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Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS.

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recommendations! Published in 2018 at "Cell systems"

DOI: 10.1016/j.cels.2018.10.010

Abstract: Viral DNA sensing is an essential component of the mammalian innate immune response. Upon binding viral DNA, the cyclic-GMP-AMP synthase (cGAS) catalyzes the production of cyclic dinucleotides to induce type I interferons. However, little is… read more here.

Keywords: dynamics uncover; cgas; interactome proteome; uncover immune ... See more keywords
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The spatial organization of cGAS-TREX1 interactions.

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recommendations! Published in 2021 at "Developmental cell"

DOI: 10.1016/j.devcel.2021.03.016

Abstract: Coupling DNA sensing to the initiation of immune responses necessitates auxiliary control mechanisms to avoid autoimmunity. A key factor is the exonuclease TREX1, which antagonizes DNA-mediated activation of cGAS. Two studies, by Mohr et al. (2021)… read more here.

Keywords: spatial organization; cgas; trex1; trex1 interactions ... See more keywords