DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity
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DOI: 10.1038/s41467-020-19941-0
Abstract: Upon sensing cytosolic DNA, the enzyme cGAS induces innate immune responses that underpin anti-microbial defenses and certain autoimmune diseases. Missense mutations of PRKDC encoding the DNA-dependent protein kinase (DNA-PK) catalytic subunit (DNA-PKcs) are associated with… read more here.
Keywords: antiviral innate; dna deficiency; cgas mediated; dna ... See more keywords
Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response
Sign Up to like & getrecommendations! Published in 2021 at "Science Advances"
DOI: 10.1126/sciadv.abc1834
Abstract: PRMT5 directly induces methylation of cGAS and inhibits cGAS-mediated antiviral immunity. Cyclic GMP-AMP synthase (cGAS) functions as an essential DNA sensor, which senses the cytoplasmic double-stranded DNA and activates the antiviral response. However, the posttranslational… read more here.
Keywords: cgas; response; mediated antiviral; cgas mediated ... See more keywords