cGAS deficiency enhances inflammasome activation in macrophages and inflammatory pathology in pristane-induced lupus
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DOI: 10.3389/fimmu.2022.1010764
Abstract: Introduction Type I interferon (IFN) plays a vital role in the pathogenesis of systemic lupus erythematosus. Cyclic GMP AMP synthase (cGAS) is a cytosolic DNA sensor that recognizes dsDNA and creates cGAMP to activate STING-mediated… read more here.
Keywords: cgas mice; pristane; pathology; activation ... See more keywords