Mathematical modeling of the cGAS pathway reveals robustness of DNA sensing to TREX1 feedback.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2018.11.001
Abstract: Cyclic GMP-AMP synthase (cGAS) has recently been identified as the primary protein that detects cytosolic double stranded DNA to invoke a type I interferon response. The cGAS pathway is vital in the recognition of DNA… read more here.
Keywords: cgas pathway; cgas; dna; model ... See more keywords
Like a Rolling Stone: Sting-Cgas Pathway and Cell-Free DNA as Biomarkers for Combinatorial Immunotherapy
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics12080758
Abstract: Combining immune checkpoint inhibitors with other treatments likely to harness tumor immunity is a rising strategy in oncology. The exact modalities of such a combinatorial regimen are yet to be defined, and most attempts have… read more here.
Keywords: immune checkpoint; cgas pathway; checkpoint inhibitors; dna ... See more keywords