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   Articles with "cgas sting" as a keyword



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Activation of cGAS‐STING by Lethal Malaria N67C Dictates Immunity and Mortality through Induction of CD11b+Ly6Chi Proinflammatory Monocytes

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recommendations! Published in 2022 at "Advanced Science"

DOI: 10.1002/advs.202103701

Abstract: Cyclic GMP‐AMP synthase (cGAS) and stimulator of interferon genes (STING) play critical roles in the innate immunity against infectious diseases and are required to link pathogen DNA sensing to immune responses. However, the mechanisms by… read more here.

Keywords: cd11b ly6chi; lethal malaria; cgas sting; proinflammatory monocytes ... See more keywords
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Phase Separation in cGAS‐STING Signaling: Cytosolic DNA Sensing and Regulatory Functions

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recommendations! Published in 2023 at "ChemBioChem"

DOI: 10.1002/cbic.202300147

Abstract: Phase separation is a crucial biophysical process that governs cellular signaling and function. This process allows biomolecules to separate and form membraneless compartments in response to both extra‐ and intra‐cellular stimuli. Recently, the identification of… read more here.

Keywords: phase separation; separation cgas; cgas sting; sting signaling ... See more keywords
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UNC93B1 attenuates the cGAS–STING signaling pathway by targeting STING for autophagy–lysosome degradation

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recommendations! Published in 2022 at "Journal of Medical Virology"

DOI: 10.1002/jmv.27860

Abstract: Stimulator of interferon genes (STING) is a pivotal innate immune adaptor, and its functions during DNA virus infections have been extensively documented. However, its homeostatic regulation is not well understood. Our study demonstrates that Unc‐93… read more here.

Keywords: autophagy lysosome; unc93b1 attenuates; cgas sting; degradation ... See more keywords
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Lipotoxicity-induced mtDNA release promotes diabetic cardiomyopathy by activating the cGAS-STING pathway in obesity-related diabetes.

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recommendations! Published in 2022 at "Cell biology and toxicology"

DOI: 10.1007/s10565-021-09692-z

Abstract: Diabetic cardiomyopathy (DCM) is characterized by lipid accumulation, mitochondrial dysfunction, and aseptic inflammatory activation. Mitochondria-derived cytosolic DNA has been reported to induce inflammation by activating cyclic GMP-AMP synthase (cGAS)/the stimulator of interferon genes (STING) pathway… read more here.

Keywords: cgas; diabetic cardiomyopathy; dcm; cgas sting ... See more keywords
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The cGAS–STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy

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recommendations! Published in 2021 at "Acta Pharmaceutica Sinica B"

DOI: 10.1016/j.apsb.2021.05.011

Abstract: Abstract The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling exert essential regulatory function in microbial-and onco-immunology through the induction of cytokines, primarily type I interferons. Recently, the aberrant and deranged signaling of the… read more here.

Keywords: cardiovascular metabolic; metabolic diseases; signaling cardiovascular; sting signaling ... See more keywords
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TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

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recommendations! Published in 2020 at "Cell"

DOI: 10.1016/j.cell.2020.09.020

Abstract: Summary Cytoplasmic accumulation of TDP-43 is a disease hallmark for many cases of amyotrophic lateral sclerosis (ALS), associated with a neuroinflammatory cytokine profile related to upregulation of nuclear factor κB (NF-κB) and type I interferon… read more here.

Keywords: cgas; tdp triggers; dna; triggers mitochondrial ... See more keywords
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Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury.

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recommendations! Published in 2019 at "Cell reports"

DOI: 10.1016/j.celrep.2019.09.050

Abstract: Acute kidney injury (AKI) is characterized by mitochondrial dysfunction and activation of the innate immune system. The cyclic GMP-AMP synthase (cGAS) stimulator of interferon genes (STING) pathway detects cytosolic DNA and induces innate immunity. Here,… read more here.

Keywords: kidney injury; cgas sting; cgas; activation ... See more keywords

Dose-related telomere damage associated with the genetic polymorphisms of cGAS/STING signaling pathway in the workers exposed by PAHs.

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recommendations! Published in 2020 at "Environmental pollution"

DOI: 10.1016/j.envpol.2020.113995

Abstract: Telomeres are located at the end of eukaryotic chromosomes and vulnerable to exogenous chemical compounds. Exposure to coke oven emissions (COEs) leads to a dose-related telomere damage, and such chromosomal damage might trigger the cGAS/STING… read more here.

Keywords: exposure; telomere damage; sting signaling; damage ... See more keywords
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cGAS-STING and Cancer: Dichotomous Roles in Tumor Immunity and Development.

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recommendations! Published in 2018 at "Trends in immunology"

DOI: 10.1016/j.it.2017.07.013

Abstract: cGMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) sensing has emerged as a key regulator of innate immune responses to both exogenous and endogenous DNA. Recent studies reveal critical roles for this pathway in natural antitumor… read more here.

Keywords: cgas; immunity; sting cancer; cgas sting ... See more keywords
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Pulmonary inflammatory and fibrogenic response induced by graphitized multi-walled carbon nanotube involved in cGAS-STING signaling pathway.

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recommendations! Published in 2021 at "Journal of hazardous materials"

DOI: 10.1016/j.jhazmat.2021.125984

Abstract: Graphitized multi-walled carbon nanotubes (GMWCNTs) are a new type of nanomaterial. Recently, their production and application in biological medicine have grown rapidly. However, GMWCNTs may cause adverse health effects, including the common occupational disease of… read more here.

Keywords: graphitized multi; fibrosis; walled carbon; sting signaling ... See more keywords
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Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING.

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recommendations! Published in 2019 at "Molecular cell"

DOI: 10.1016/j.molcel.2019.02.038

Abstract: Interleukin-1 beta (IL-1β) is a pleiotropic mediator of inflammation and is produced in response to a wide range of stimuli. During infection, IL-1β production occurs in parallel with the onset of innate antimicrobial defenses, but… read more here.

Keywords: innate; induces mtdna; cgas sting; innate immune ... See more keywords