Sequence-dependent inhibition of cGAS and TLR9 DNA sensing by 2′-O-methyl gapmer oligonucleotides
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DOI: 10.1093/nar/gkab451
Abstract: Abstract Oligonucleotide-based therapeutics have the capacity to engage with nucleic acid immune sensors to activate or block their response, but a detailed understanding of these immunomodulatory effects is currently lacking. We recently showed that 2′-O-methyl… read more here.
Keywords: cgas; inhibition; tlr9; cgas tlr9 ... See more keywords