Point mutations in Candida glabrata 3-hydroxy-3-methylglutaryl-coenzyme A reductase (CgHMGR) decrease enzymatic activity and substrate/inhibitor affinity
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DOI: 10.1038/s41598-021-00356-w
Abstract: 3-Hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) is a crucial enzyme in the ergosterol biosynthesis pathway. The aim of this study was to obtain, purify, characterize, and overexpress five point mutations in highly conserved regions of the catalytic… read more here.
Keywords: enzymatic activity; cghmgr; hydroxy methylglutaryl; site ... See more keywords