Characterization of Competitive Inhibitors of Plasmodium falciparum cGMP‐Dependent Protein Kinase **
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DOI: 10.1002/cbic.202100704
Abstract: Plasmodium falciparum cGMP‐dependent protein kinase (PfPKG) is an enticing antimalarial drug target. Novel chemotypes are needed because existing inhibitors have safety issues that may prevent further development. This work demonstrates isoxazole‐based compounds are potent ATP… read more here.
Keywords: plasmodium falciparum; protein kinase; competitive inhibitors; falciparum cgmp ... See more keywords
Natriuretic peptides promote glucose uptake in a cGMP-dependent manner in human adipocytes
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DOI: 10.1038/s41598-018-19619-0
Abstract: Robust associations between low plasma level of natriuretic peptides (NP) and increased risk of type 2 diabetes (T2D) have been recently reported in humans. Adipose tissue (AT) is a known target of NP. However it… read more here.
Keywords: glucose uptake; cgmp dependent; human adipocytes; dependent manner ... See more keywords
Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1905558116
Abstract: Significance Despite being one of the first protein kinases discovered, cyclic guanosine-3′,5′-monophosphate (cGMP)-dependent protein kinase (PKG) has not been successfully crystallized previously, leaving many unanswered questions about its mechanism of activation. We report herein the… read more here.
Keywords: protein; mechanism; kinase; pkg ... See more keywords
Programmed Non-Apoptotic Cell Death in Hereditary Retinal Degeneration: Crosstalk between cGMP-Dependent Pathways and PARthanatos?
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DOI: 10.3390/ijms221910567
Abstract: Programmed cell death (PCD) is a highly regulated process that results in the orderly destruction of a cell. Many different forms of PCD may be distinguished, including apoptosis, PARthanatos, and cGMP-dependent cell death. Misregulation of… read more here.
Keywords: cell; cgmp dependent; parthanatos; cell death ... See more keywords