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   Articles with "cgmp dependent" as a keyword



Characterization of Competitive Inhibitors of Plasmodium falciparum cGMP‐Dependent Protein Kinase **

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recommendations! Published in 2022 at "ChemBioChem"

DOI: 10.1002/cbic.202100704

Abstract: Plasmodium falciparum cGMP‐dependent protein kinase (PfPKG) is an enticing antimalarial drug target. Novel chemotypes are needed because existing inhibitors have safety issues that may prevent further development. This work demonstrates isoxazole‐based compounds are potent ATP… read more here.

Keywords: plasmodium falciparum; protein kinase; competitive inhibitors; falciparum cgmp ... See more keywords

Natriuretic peptides promote glucose uptake in a cGMP-dependent manner in human adipocytes

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recommendations! Published in 2018 at "Scientific Reports"

DOI: 10.1038/s41598-018-19619-0

Abstract: Robust associations between low plasma level of natriuretic peptides (NP) and increased risk of type 2 diabetes (T2D) have been recently reported in humans. Adipose tissue (AT) is a known target of NP. However it… read more here.

Keywords: glucose uptake; cgmp dependent; human adipocytes; dependent manner ... See more keywords
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Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation

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recommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.1905558116

Abstract: Significance Despite being one of the first protein kinases discovered, cyclic guanosine-3′,5′-monophosphate (cGMP)-dependent protein kinase (PKG) has not been successfully crystallized previously, leaving many unanswered questions about its mechanism of activation. We report herein the… read more here.

Keywords: protein; mechanism; kinase; pkg ... See more keywords

cGMP-dependent pathway and a GPCR kinase are required for photoresponse in the nematode Pristionchus pacificus

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recommendations! Published in 2024 at "PLOS Genetics"

DOI: 10.1371/journal.pgen.1011320

Abstract: Light sensing is a critical function in most organisms and is mediated by photoreceptor proteins and phototransduction. Although most nematodes lack eyes, some species exhibit phototaxis. In the nematode Caenorhabditis elegans, the unique photoreceptor protein… read more here.

Keywords: cgmp dependent; light sensing; light avoidance; pristionchus pacificus ... See more keywords

Programmed Non-Apoptotic Cell Death in Hereditary Retinal Degeneration: Crosstalk between cGMP-Dependent Pathways and PARthanatos?

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recommendations! Published in 2021 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms221910567

Abstract: Programmed cell death (PCD) is a highly regulated process that results in the orderly destruction of a cell. Many different forms of PCD may be distinguished, including apoptosis, PARthanatos, and cGMP-dependent cell death. Misregulation of… read more here.

Keywords: cell; cgmp dependent; parthanatos; cell death ... See more keywords