Do cGMP Levels Drive the Speed of Photoreceptor Degeneration?
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-75402-4_40
Abstract: Humans with mutations in the phototransduction pathway develop forms of retinal degeneration, such as retinitis pigmentosa, cone dystrophy, or Leber congenital amaurosis. Similarly, numerous phototransduction mutant animal models resemble retinal degeneration. In our lab, using… read more here.
Keywords: photoreceptor degeneration; speed photoreceptor; photoreceptor; cgmp levels ... See more keywords
Elevated retinal cGMP is not associated with elevated circulating cGMP levels in a canine model of retinitis pigmentosa
Sign Up to like & getrecommendations! Published in 2022 at "PLOS ONE"
DOI: 10.1371/journal.pone.0279437
Abstract: Purpose To investigate whether raised levels of retinal cyclic guanosine monophosphate (cGMP) was reflected in plasma levels in PDE6A-/- dogs. Materials and methods Retina was collected from 2-month-old wildtype dogs (PDE6A+/+, N = 6), heterozygous… read more here.
Keywords: pde6a puppies; cgmp levels; cgmp; retinal cgmp ... See more keywords