The environmental pollutant BDE-209 regulates NO/cGMP signaling through activation of NMDA receptors in neurons
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-017-0651-5
Abstract: The common flame retardant decabrominated diphenyl ether (BDE-209) is a persistent organic pollutant. Epidemiological studies have revealed that prenatal or postnatal exposure to BDE-209 can result in delayed cognitive development, and BDE-209 has been shown… read more here.
Keywords: bde; activation nmda; cgmp signaling; bde 209 ... See more keywords
An inherent dysfunction in soluble guanylyl cyclase is present in the airway of severe asthmatics and is associated with aberrant redox enzyme expression and compromised NO-cGMP signaling
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101832
Abstract: A subset of asthmatics develop a severe form of the disease whose etiology involves airway inflammation along with inherent drivers that remain ill-defined. To address this, we studied human airway smooth muscle cells (HASMC), whose… read more here.
Keywords: dysfunction; severe asthma; redox; cgmp signaling ... See more keywords
Phosphodiesterase 2 inhibition preferentially promotes NO/guanylyl cyclase/cGMP signaling to reverse the development of heart failure
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1800996115
Abstract: Significance The morbidity and mortality associated with heart failure (HF) are unacceptably high. Cyclic guanosine-3′,5′-monophosphate (cGMP) plays a key role in preserving cardiac structure and function, and therapeutically targeting cGMP in HF has shown promise… read more here.
Keywords: inhibition; cgmp; heart failure; cgmp signaling ... See more keywords
Nitric Oxide-cGMP Signaling in Hypertension: Current and Future Options for Pharmacotherapy.
Sign Up to like & getrecommendations! Published in 2020 at "Hypertension"
DOI: 10.1161/hypertensionaha.120.15856
Abstract: For the treatment of systemic hypertension, pharmacological intervention in nitric oxide-cyclic guanosine monophosphate signaling is a well-explored but unexploited option. In this review, we present the identified drug targets, including oxidases, mitochondria, soluble guanylyl cyclase,… read more here.
Keywords: cgmp signaling; hypertension current; nitric oxide; hypertension ... See more keywords
Ablation of C-type natriuretic peptide/cGMP signaling in fibroblasts exacerbates adverse cardiac remodeling in mice.
Sign Up to like & getrecommendations! Published in 2023 at "JCI insight"
DOI: 10.1172/jci.insight.160416
Abstract: Excessive activation of cardiac fibroblasts (CFs) in response to injury provokes cardiac fibrosis, stiffness, and failure. The local mediators counter-regulating this response remain unclear. Exogenous C-type natriuretic peptide (CNP) exerted antifibrotic effects in preclinical models.… read more here.
Keywords: cgmp signaling; type natriuretic; natriuretic peptide; cardiac remodeling ... See more keywords
ROS and cGMP signaling modulate persistent escape from hypoxia in Caenorhabditis elegans
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Biology"
DOI: 10.1371/journal.pbio.3001684
Abstract: The ability to detect and respond to acute oxygen (O2) shortages is indispensable to aerobic life. The molecular mechanisms and circuits underlying this capacity are poorly understood. Here, we characterize the behavioral responses of feeding… read more here.
Keywords: cgmp; caenorhabditis elegans; cgmp signaling; escape hypoxia ... See more keywords
L-Arginine reverses maternal and pre-pubertal codeine exposure-induced sexual dysfunction via upregulation of androgen receptor gene and NO/cGMP signaling
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0274411
Abstract: Background Although codeine has been reported to enhance sexual activity by improving penile reflexes, it has been shown to impair fertility indices. Also, codeine impairs ovarian steroidogenesis and folliculogenesis. Nonetheless, whether or not codeine exerts… read more here.
Keywords: codeine; androgen receptor; arginine; cgmp signaling ... See more keywords
cGMP Signaling in the Neurovascular Unit—Implications for Retinal Ganglion Cell Survival in Glaucoma
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12111671
Abstract: Glaucoma is a progressive age-related disease of the visual system and the leading cause of irreversible blindness worldwide. Currently, intraocular pressure (IOP) is the only modifiable risk factor for the disease, but even as IOP… read more here.
Keywords: glaucoma; neurovascular unit; cgmp signaling; pathology ... See more keywords
Dysfunctional cGMP Signaling Leads to Age-Related Retinal Vascular Alterations and Astrocyte Remodeling in Mice
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23063066
Abstract: The nitric oxide–guanylyl cyclase-1–cyclic guanylate monophosphate (NO–GC-1–cGMP) pathway is integral to the control of vascular tone and morphology. Mice lacking the alpha catalytic domain of guanylate cyclase (GC1−/−) develop retinal ganglion cell (RGC) degeneration with… read more here.
Keywords: age; gc1 mice; mice; cgmp ... See more keywords
cGMP signaling: a potential therapeutic target for neurodegeneration in glaucoma?
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.360169
Abstract: Neurodegeneration of the central nervous system (CNS) underscores many of humanity’s most debilitating diseases, including Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. Recently, the nitric oxide-guanylate cyclase-cyclic guanosine monophosphate (NOGC-cGMP) signaling pathway has gained traction… read more here.
Keywords: signaling potential; glaucoma; cgmp; cgmp signaling ... See more keywords