Salivary CGRP and Erenumab Treatment Response: Towards Precision Medicine in Migraine
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26472
Abstract: We aimed (1) to analyze salivary calcitonin gene‐related peptide (CGRP) levels in patients with migraine, (2) to predict erenumab response from baseline CGRP levels, and (3) to evaluate CGRP change post‐treatment. read more here.
Keywords: cgrp; salivary cgrp; cgrp erenumab; treatment ... See more keywords
CGRP induces myofibroblast differentiation and the production of extracellular matrix in MRC5s via autocrine and paracrine signalings
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23204
Abstract: There are contradictory views on which calcitonin gene‐related peptide (CGRP) causes pulmonary fibrosis. Fibrotic potency of CGRP was tested and compared to that of transforming growth factor‐β (TGF‐β). Myofibroblast differentiation, cell proliferation, and activations of… read more here.
Keywords: myofibroblast differentiation; extracellular matrix; cgrp; production ... See more keywords
Involvement of CGRP‐RCP in the caveolin‐1/ERK1/2 signal pathway in the static pressure‐induced proliferation of vascular smooth muscle cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26582
Abstract: Previous study suggested that the receptor component protein (RCP), one of the components of calcitonin gene‐related peptide (CGRP) receptor, plays a multiple role in the cellular signal transduction. The study was designed to investigate whether… read more here.
Keywords: cgrp; proliferation; static pressure; caveolin ... See more keywords
CGRP Discovery and Timeline.
Sign Up to like & getrecommendations! Published in 2018 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2018_129
Abstract: Calcitonin gene-related peptide (CGRP) was discovered over about 35 years ago through molecular biological techniques. Its activity as a vasodilator and the proposal that it was involved in pain processing were then soon established. Today, we… read more here.
Keywords: cgrp; discovery timeline; pharmacology; cgrp discovery ... See more keywords
Calcitonin Gene-Related Peptide Antagonists and Therapeutic Antibodies.
Sign Up to like & getrecommendations! Published in 2019 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2018_173
Abstract: The calcitonin gene-related peptide (CGRP) receptor is composed of the calcitonin receptor-like receptor (CLR, a class B GPCR) and a single-pass membrane protein known as receptor activity modifying protein type 1 (RAMP1). The levels of… read more here.
Keywords: cgrp; related peptide; gene related; calcitonin gene ... See more keywords
CGRP and Painful Pathologies Other than Headache.
Sign Up to like & getrecommendations! Published in 2019 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2019_242
Abstract: CGRP has long been suspected as a mediator of arthritis pain, although evidence that CGRP directly mediates human musculoskeletal pain remains circumstantial. This chapter describes in depth the evidence surrounding CGRP's association with pain in… read more here.
Keywords: musculoskeletal pain; cgrp; cgrp painful; pathologies headache ... See more keywords
Do anti-CGRP drugs have a role in migraine aura therapy?
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neurology"
DOI: 10.1007/s00415-021-10546-1
Abstract: Migraine is a complex neurological disorder whose biologic underpinnings have not been completely unravelled [1]. The trigeminovascular system (TVS) is the main mediator of pain generation in migraine and its activation usually follows a cortical… read more here.
Keywords: migraine aura; migraine; cgrp; frequency ... See more keywords
Exogenous CGRP upregulates profibrogenic growth factors through PKC/JNK signaling pathway in kidney proximal tubular cells
Sign Up to like & getrecommendations! Published in 2017 at "Cell Biology and Toxicology"
DOI: 10.1007/s10565-017-9399-4
Abstract: Kidney denervation prevents the development of tubulointerstitial fibrosis, but the neuropeptide calcitonin gene-related peptide (CGRP) in the denervated kidneys restores the fibrotic feature through the upregulation of profibrogenic growth factors. CGRP is involved in aggravation… read more here.
Keywords: cgrp; tgf ctgf; exogenous cgrp; growth ... See more keywords
Neuropeptides as a Marker for Chronic Headache
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DOI: 10.1007/s11916-017-0618-8
Abstract: Purpose of ReviewThe purpose of this review is to revise current evidence on trigemino-vascular system (TVS) neuropeptides as potential biomarkers for chronic primary headaches, mainly for chronic migraine (CM).Recent FindingsWithin sensory neuropeptides, released by an… read more here.
Keywords: migraine; cgrp; neuropeptides marker; marker chronic ... See more keywords
Is calcitonin gene-related peptide a modulator of menopausal vasomotor symptoms?
Sign Up to like & getrecommendations! Published in 2018 at "Endocrine"
DOI: 10.1007/s12020-018-1777-z
Abstract: PurposeCalcitonin gene-related peptide (CGRP) is a neuropeptide widely distributed in the central and peripheral nervous systems, which is known as a potent vasodilator. Postmenopausal women who experience hot flushes have high levels of plasma CGRP,… read more here.
Keywords: menopausal vasomotor; cgrp; related peptide; gene related ... See more keywords
An Intraperitoneal Treatment with Calcitonin Gene-Related Peptide (CGRP) Regulates Appetite, Energy Intake/Expenditure, and Metabolism
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-018-1202-3
Abstract: Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide expressed both centrally and peripherally. CGRP has been shown to be involved in arteriolar dilation, cardiovascular regulation, pain transmission, migraine, and gastrointestinal physiology. Our current research… read more here.
Keywords: energy; cgrp; metabolism; treatment ... See more keywords