The CH1α domain of mucosal gp41 IgA contributes to antibody specificity and antiviral functions in HIV-1 highly exposed Sero-Negative individuals
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DOI: 10.1371/journal.ppat.1009103
Abstract: The antibody molecule comprises a variable domain conferring antigen specificity and affinity distinct from the heavy chain constant (CH) domains dictating effector functions. We here interrogate this paradigm by evaluating the unique influence of the… read more here.
Keywords: hiv highly; mucosal gp41; domain; ch1 domain ... See more keywords
Quantitative Visualization of the Interaction between Complement Component C1 and Immunoglobulin G: The Effect of CH1 Domain Deletion
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DOI: 10.3390/ijms23042090
Abstract: Immunoglobulin G (IgG) adopts a modular multidomain structure that mediates antigen recognition and effector functions, such as complement-dependent cytotoxicity. IgG molecules are self-assembled into a hexameric ring on antigen-containing membranes, recruiting the complement component C1q.… read more here.
Keywords: ch1 domain; quantitative visualization; domain; interaction ... See more keywords