Tolerability, response and outcome of high-risk neuroblastoma patients treated with long-term infusion of anti-GD2 antibody ch14.18/CHO
Sign Up to like & getrecommendations! Published in 2018 at "mAbs"
DOI: 10.1080/19420862.2017.1402997
Abstract: ABSTRACT Immunotherapy with short term infusion (STI) of monoclonal anti-GD2 antibody (mAb) ch14.18 (4 × 25 mg/m2/d; 8–20 h) in combination with cytokines and 13-cis retinoic acid (RA) prolonged survival in high-risk neuroblastoma (NB) patients.… read more here.
Keywords: risk; response; ch14 cho; high risk ... See more keywords
PD-1 blockade augments anti-neuroblastoma immune response induced by anti-GD2 antibody ch14.18/CHO
Sign Up to like & getrecommendations! Published in 2017 at "OncoImmunology"
DOI: 10.1080/2162402x.2017.1343775
Abstract: ABSTRACT Immunotherapy with anti-GD2 antibody (Ab) ch14.18/CHO is effective for treatment of high-risk neuroblastoma (NB) patients and is mainly based on GD2-specific Ab-dependent cellular cytotoxicity (ADCC). Strategies to further enhance the efficacy are important and… read more here.
Keywords: anti gd2; cho; blockade; ch14 cho ... See more keywords
Association of regulatory- and helper-T- cells with inferior survival of neuroblastoma patients treated with long-term infusion of ch14.18/CHO combined with interleukin-2.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.10530
Abstract: 10530Background: Long-term infusion (LTI) of the anti-GD2 antibody (Ab) ch14.18/CHO in combination with interleukin-2 (IL-2) prolongs survival in patients (pts) with high-risk neuroblastoma compare... read more here.
Keywords: term infusion; long term; association regulatory; ch14 cho ... See more keywords
Anti-GD2-ch14.18/CHO coated nanoparticles mediate glioblastoma (GBM)-specific delivery of the aromatase inhibitor, Letrozole, reducing proliferation, migration and chemoresistance in patient-derived GBM tumor cells
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DOI: 10.18632/oncotarget.15073
Abstract: Aromatase is a critical enzyme in the irreversible conversion of androgens to oestrogens, with inhibition used clinically in hormone-dependent malignancies. We tested the hypothesis that targeted aromatase inhibition in an aggressive brain cancer called glioblastoma… read more here.
Keywords: inhibitor; ch14 cho; anti gd2; gbm ... See more keywords
Translational immunoPET imaging using a radiolabeled GD2-specific antibody in neuroblastoma
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DOI: 10.7150/thno.56736
Abstract: Background: Antibodies targeting surface expressed disialoganglioside GD2 are increasingly used in neuroblastoma immunotherapy and might also have potential for use in radioimmunotherapy. As such targeted treatments might benefit from a dedicated theranostic approach, we studied… read more here.
Keywords: ch14 cho; gd2; translational immunopet; antibody ... See more keywords