Enzymatic Degradation of Cortical Perineuronal Nets Reverses GABAergic Interneuron Maturation.
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DOI: 10.1007/s12035-022-02772-z
Abstract: Perineuronal nets (PNNs) are specialised extracellular matrix structures which preferentially enwrap fast-spiking (FS) parvalbumin interneurons and have diverse roles in the cortex. PNN maturation coincides with closure of the critical period of cortical plasticity. We… read more here.
Keywords: perineuronal nets; chabc; maturation; enzymatic degradation ... See more keywords
Impaired Cognitive Function after Perineuronal Net Degradation in the Medial Prefrontal Cortex
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DOI: 10.1523/eneuro.0253-18.2018
Abstract: Abstract Perineuronal nets (PNNs) are highly organized components of the extracellular matrix that surround a subset of mature neurons in the CNS. These structures play a critical role in regulating neuronal plasticity, particularly during neurodevelopment.… read more here.
Keywords: chabc treated; mpfc; cognitive function; chabc ... See more keywords