Enzymatic Degradation of Cortical Perineuronal Nets Reverses GABAergic Interneuron Maturation.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular neurobiology"
DOI: 10.1007/s12035-022-02772-z
Abstract: Perineuronal nets (PNNs) are specialised extracellular matrix structures which preferentially enwrap fast-spiking (FS) parvalbumin interneurons and have diverse roles in the cortex. PNN maturation coincides with closure of the critical period of cortical plasticity. We… read more here.
Keywords: perineuronal nets; chabc; maturation; enzymatic degradation ... See more keywords
Impaired Cognitive Function after Perineuronal Net Degradation in the Medial Prefrontal Cortex
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DOI: 10.1523/eneuro.0253-18.2018
Abstract: Abstract Perineuronal nets (PNNs) are highly organized components of the extracellular matrix that surround a subset of mature neurons in the CNS. These structures play a critical role in regulating neuronal plasticity, particularly during neurodevelopment.… read more here.
Keywords: chabc treated; mpfc; cognitive function; chabc ... See more keywords
Chondroitinase ABC in Neural Regeneration: Advances in CNS and Peripheral Nerve Repair.
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DOI: 10.2174/0113816128392818251012115510
Abstract: Chondroitinase ABC (ChABC) is a bacterial enzyme that can potentially address the inhibitory effects of Chondroitin Sulfate Proteoglycans (CSPGs) in various neurological disorders and injuries. CSPGs are key components of the extracellular matrix that, when… read more here.
Keywords: chondroitinase abc; repair; chabc; peripheral nerve ... See more keywords