CHAC1 as a novel biomarker for distinguishing alopecia from other dermatological diseases and determining its severity
Sign Up to like & getrecommendations! Published in 2022 at "IET Systems Biology"
DOI: 10.1049/syb2.12048
Abstract: Abstract Alopecia Areata (AA) is characterised by an autoimmune response to hair follicles (HFs) and its exact pathobiology remains unclear. The current study aims to look into the molecular changes in the skin of AA… read more here.
Keywords: chac1; chac1 novel; novel biomarker; biomarker distinguishing ... See more keywords
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) increases kidney disease risk by modulating ferroptosis.
Sign Up to like & getrecommendations! Published in 2025 at "Science translational medicine"
DOI: 10.1126/scitranslmed.adn3079
Abstract: Genome-wide association studies (GWASs) have identified more than 1000 loci where genetic variants correlate with kidney function. However, the specific genes, cell types, and mechanisms influenced by these genetic variants remain largely uncharted. Here, we… read more here.
Keywords: disease; glutathione; kidney disease; ferroptosis ... See more keywords
Abstract PO5-24-08: Differential exploitation of Cation Transport Regulator homolog 1 (CHAC1) by Wild-type and mutant p53
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs23-po5-24-08
Abstract: Background: Cancer cells are constantly exposed to harsh conditions like nutrient deprivation, hypoxia, and calcium imbalance leading to the induction of UPR. In its early phase, UPR aims to restore homeostasis while prolonged stress leads… read more here.
Keywords: p53; chac1; mutant p53; breast cancer ... See more keywords
CHAC1 inactivation is effective to preserve muscle glutathione but is insufficient to protect against muscle wasting in cachexia
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0283806
Abstract: Muscle wasting is one of the main characteristics of cachexia associated with cancer and other chronic diseases and is often exacerbated by antineoplastic agents. Increased oxidative stress is associated with muscle wasting, along with depletion… read more here.
Keywords: chac1; muscle glutathione; muscle wasting; preserve muscle ... See more keywords
Sevoflurane Induces Ferroptosis of Glioma Cells Through Activating the ATF4-CHAC1 Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.859621
Abstract: Objective To clarify the function and mechanisms of sevoflurane (Sev) on ferroptosis in glioma cells. Methods Different concentrations of Sev were used to treat glioma cells U87 and U251. Ferroptosis inducer Erastin was used to… read more here.
Keywords: chac1; u87 u251; glioma cells; u251 cells ... See more keywords
Prognostic Values of Ferroptosis-Related Proteins ACSL4, SLC7A11, and CHAC1 in Cholangiocarcinoma
Sign Up to like & getrecommendations! Published in 2024 at "Biomedicines"
DOI: 10.3390/biomedicines12092091
Abstract: Background: The epithelial malignant tumor known as cholangiocarcinoma (CCA) is most commonly found in Southeast Asia, particularly in northeastern Thailand. Previous research has indicated that the overexpression of acyl-CoA synthetase long-chain family member 4 (ACSL4),… read more here.
Keywords: cca; ferroptosis related; slc7a11 chac1; related proteins ... See more keywords