Habitat amount, quality, and fragmentation associated with prevalence of the tick-borne pathogen Ehrlichia chaffeensis and occupancy dynamics of its vector, Amblyomma americanum
Sign Up to like & getrecommendations! Published in 2019 at "Landscape Ecology"
DOI: 10.1007/s10980-019-00898-5
Abstract: Tick-borne diseases are becoming increasingly prevalent world-wide. This is likely due in part to land-cover change, particularly forest fragmentation, but this evidence is largely limited to Lyme disease. It is unknown whether this is generalizable… read more here.
Keywords: pathogen; tick; chaffeensis; prevalence ... See more keywords
Ehrlichia chaffeensis TRP120 Moonlights as a HECT E3 Ligase Involved in Self- and Host Ubiquitination To Influence Protein Interactions and Stability for Intracellular Survival
Sign Up to like & getrecommendations! Published in 2017 at "Infection and Immunity"
DOI: 10.1128/iai.00290-17
Abstract: ABSTRACT Ehrlichia chaffeensis secretes tandem repeat protein (TRP) effectors that are involved in a diverse array of host cell interactions, some of which directly activate cell signaling pathways and reprogram host gene transcription to promote… read more here.
Keywords: protein; chaffeensis; trp120; host ... See more keywords
Ehrlichia chaffeensis TRP120 Effector Targets and Recruits Host Polycomb Group Proteins for Degradation To Promote Intracellular Infection
Sign Up to like & getrecommendations! Published in 2018 at "Infection and Immunity"
DOI: 10.1128/iai.00845-17
Abstract: ABSTRACT Ehrlichia chaffeensis has a group of well-characterized type I secreted tandem repeat protein (TRP) effectors that have moonlighting capabilities. TRPs modulate various cellular processes, reprogram host gene transcription as nucleomodulins, function as ubiquitin ligases,… read more here.
Keywords: polycomb; infection; group; chaffeensis ... See more keywords
Mutations in Ehrlichia chaffeensis Genes ECH_0660 and ECH_0665 Cause Transcriptional Changes in Response to Zinc or Iron Limitation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Bacteriology"
DOI: 10.1128/jb.00027-21
Abstract: Ehrlichia chaffeensis, a tick-transmitted bacterium, causes human monocytic ehrlichiosis by replicating within phagosomes of monocytes/macrophages. A function disruption mutation within the pathogen’s gene encoding a phage head-to-tail connector protein resulted in the rapid clearance of… read more here.
Keywords: pathogen; chaffeensis; zinc iron; gene ... See more keywords
Ehrlichia SLiM Ligand Mimetic Activates Notch Signaling in Human Monocytes
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DOI: 10.1128/mbio.00076-22
Abstract: E. chaffeensis infects and replicates in mononuclear phagocytes, but how it evades innate immune defenses of this indispensable primary innate immune cell is not well understood. This investigation revealed the molecular details of a ligand… read more here.
Keywords: chaffeensis; notch signaling; cell; trp120 ... See more keywords
Ehrlichia chaffeensis and Its Invasin EtpE Block Reactive Oxygen Species Generation by Macrophages in a DNase X-Dependent Manner
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DOI: 10.1128/mbio.01551-17
Abstract: ABSTRACT The obligatory intracellular pathogen Ehrlichia chaffeensis lacks most genes that confer resistance to oxidative stress but can block reactive oxygen species (ROS) generation by host monocytes-macrophages. Bacterial and host molecules responsible for this inhibition… read more here.
Keywords: dnase; etpe; chaffeensis; generation ... See more keywords
Initial development and preliminary evaluation of a multiplex bead assay to detect antibodies to Ehrlichia canis, Anaplasma platys, and Ehrlichia chaffeensis outer membrane peptides in naturally infected dogs from Grenada, West Indies
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Veterinary Diagnostic Investigation"
DOI: 10.1177/1040638716671979
Abstract: Tick-borne bacteria, Ehrlichia canis, Anaplasma platys, and Ehrlichia chaffeensis are significant pathogens of dogs worldwide, and coinfections of E. canis and A. platys are common in dogs on the Caribbean islands. We developed and evaluated… read more here.
Keywords: platys; canis anaplasma; chaffeensis; canis ... See more keywords
Ehrlichia SLiM ligand mimetic activates Hedgehog signaling to engage a BCL-2 anti-apoptotic cellular program
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010345
Abstract: Ehrlichia chaffeensis (E. chaffeensis) has evolved eukaryotic ligand mimicry to repurposes multiple cellular signaling pathways for immune evasion. In this investigation, we demonstrate that TRP120 has a novel repetitive short liner motif (SLiM) that activates… read more here.
Keywords: chaffeensis; cellular program; anti apoptotic; infection ... See more keywords
Peptide Nucleic Acid Knockdown and Intra-host Cell Complementation of Ehrlichia Type IV Secretion System Effector
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2017.00228
Abstract: Survival of Ehrlichia chaffeensis depends on obligatory intracellular infection. One of the barriers to E. chaffeensis research progress has been the inability, using conventional techniques, to generate knock-out mutants for genes essential for intracellular infection.… read more here.
Keywords: infection; chaffeensis; host cell; host ... See more keywords
The “Biological Weapons” of Ehrlichia chaffeensis: Novel Molecules and Mechanisms to Subjugate Host Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2021.830180
Abstract: Ehrlichia chaffeensis is an obligatory intracellular bacterium that causes human monocytic ehrlichiosis, an emerging, potentially fatal tick-borne infectious disease. The bacterium enters human cells via the binding of its unique outer-membrane invasin EtpE to the… read more here.
Keywords: chaffeensis; ehrlichia chaffeensis; host cells; host ... See more keywords
CtrA activates the expression of glutathione S-transferase conferring oxidative stress resistance to Ehrlichia chaffeensis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.1081614
Abstract: Ehrlichia chaffeensis, the causative agent of human monocytic ehrlichiosis (HME), is a Gram-negative obligatory intracellular bacterium, which infects and multiplies in human monocytes and macrophages. Host immune cells produce reactive oxygen species (ROS) to eliminate… read more here.
Keywords: chaffeensis; chaffeensis ctra; oxidative stress; glutathione ... See more keywords