Risk of Chronic Cardiomyopathy Among Patients With the Acute Phase or Indeterminate Form of Chagas Disease
Sign Up to like & getrecommendations! Published in 2020 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2020.15072
Abstract: Key Points Question What is the risk of developing cardiomyopathy among patients with the acute phase of Chagas infection or the indeterminate chronic form of Chagas disease? Findings In this systematic review and meta-analysis of… read more here.
Keywords: among patients; patients acute; chagas; cardiomyopathy among ... See more keywords
Lack of Association of IL6 polymorphism with the susceptibility to Chagas disease in Latin American populations.
Sign Up to like & getrecommendations! Published in 2020 at "Acta tropica"
DOI: 10.1016/j.actatropica.2020.105546
Abstract: The aim of the present study was to analyze IL6 rs1800795 genetic variant in the susceptibility to Trypanosoma cruzi infection and in the development of chronic Chagas cardiomyopathy (CCC), in five independent Latin American cohorts.… read more here.
Keywords: susceptibility; il6; chagas; il6 rs1800795 ... See more keywords
[Seroprevalence and vertical transmission of Chagas disease in a cohort of Latin-american pregnant women in a tertiary hospital in Madrid].
Sign Up to like & getrecommendations! Published in 2018 at "Anales De Pediatria"
DOI: 10.1016/j.anpede.2017.03.020
Abstract: Abstract Background Chagas disease, caused by Trypanosoma cruzi (T. cruzi), is endemic in Latin-America and is emerging in Spain due to immigration. The vertical transmission rate is around 5%. A routine prenatal screening with serology… read more here.
Keywords: serology; pregnant women; chagas; disease ... See more keywords
Chagas disease research and development: Is there light at the end of the tunnel?
Sign Up to like & getrecommendations! Published in 2017 at "Computational and Structural Biotechnology Journal"
DOI: 10.1016/j.csbj.2016.12.002
Abstract: Chagas disease, or American trypanosomiasis, is the result of infection by the parasite Trypanosoma cruzi. It is endemic in Latin America, and spreading around the globe due to human migration. Although it was first identified… read more here.
Keywords: disease research; research development; chagas; disease ... See more keywords
Chitosan grafted into mesoporous silica nanoparticles as benznidazol carrier for Chagas diseases treatment
Sign Up to like & getrecommendations! Published in 2018 at "Microporous and Mesoporous Materials"
DOI: 10.1016/j.micromeso.2018.06.035
Abstract: Abstract The use of chitosan functionalized silica for benznidazole delivery in the treatment of neglected disease such as Chagas disease is one of the forms not yet explored, but with great potential for this therapy,… read more here.
Keywords: chagas disease; benznidazole delivery; treatment; chagas ... See more keywords
Optimization and evaluation of the ARCHITECT Chagas assay and in-house ELISA for Chagas disease in clinical settings in Japan.
Sign Up to like & getrecommendations! Published in 2020 at "Parasitology international"
DOI: 10.1016/j.parint.2020.102221
Abstract: Approximately 250,000 immigrants from Latin America live in Japan and it is estimated that 1500-3000 of them are potentially infected with Trypanosoma cruzi, the cause of Chagas disease. Therefore, the establishment of a standardized diagnostic… read more here.
Keywords: japan; chagas disease; chagas; architect chagas ... See more keywords
DIAGNOSTIC UTILITY OF GOLDBERGER'S ELECTROCARDIOGRAPHIC TRIAD IN PREDICTING LEFT VENTRICULAR DYSFUNCTION IN CHAGAS’ HEART DISEASE
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(17)34296-1
Abstract: Background: Chagas’ disease is a serious problem in Latin America. Clinical settings where is managed might be limited; therefore simple diagnostic tools are needed to improve detection. Goldberger's electrocardiographic triad (SV1 or SV2 + RV5… read more here.
Keywords: goldberger electrocardiographic; disease; electrocardiographic triad; chagas ... See more keywords
PP107 Amiodarone For Arrhythmia In Chagas Patients: A Systematic Review
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Technology Assessment in Health Care"
DOI: 10.1017/s0266462317002689
Abstract: INTRODUCTION: Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is a neglected chronic condition with a high burden of morbidity and mortality. It affects about 6 million people in twenty-one countries of Latin America,… read more here.
Keywords: systematic review; amiodarone; chagas; amiodarone arrhythmia ... See more keywords
Novel Diarylthioether Compounds as Agents for the Treatment of Chagas Disease.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01725
Abstract: Herein, we describe the hit optimization of a novel diarylthioether chemical class found to be active against Trypanosoma cruzi; the parasite responsible for Chagas disease. The hit compound was discovered through a whole-cell phenotypic screen… read more here.
Keywords: diarylthioether compounds; novel diarylthioether; chagas disease; chagas ... See more keywords
Genetic Characterization of Trypanosoma cruzi I Populations from an Oral Chagas Disease Outbreak in Venezuela: Natural Resistance to Nitroheterocyclic Drugs.
Sign Up to like & getrecommendations! Published in 2023 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.2c00569
Abstract: The oral transmission of Chagas disease (oCD) in Venezuela announced its appearance in 2007. Different from other populations affected by oCD and despite close supervision during treatment with nitroheterocyclic drugs, the result was treatment failure.… read more here.
Keywords: chagas disease; nitroheterocyclic drugs; trypanosoma cruzi; post ... See more keywords
Spanish group defeats Shkreli in Chagas voucher race
Sign Up to like & getrecommendations! Published in 2017 at "Nature Biotechnology"
DOI: 10.1038/nbt1117-1003
Abstract: 1003 Chemo submitted that package to the FDA, gaining an approval and a PRV. “We were already working with the regulator to set out the requirements for registration,” says DNDi’s Ribeiro. “For us it was… read more here.
Keywords: chagas; disease; drug; group defeats ... See more keywords