Long-term Survival Following Heart Transplantation for Chagas Versus Non-Chagas Cardiomyopathy: A Single-center Experience in Northeastern Brazil Over 2 Decades
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DOI: 10.1097/txd.0000000000001349
Abstract: Background. Data on post–heart transplant (HT) survival of patients with Chagas cardiomyopathy (CC) are scarce. We sought to evaluate post-HT survival in patients with CC as compared with other causes of heart failure across different… read more here.
Keywords: survival; heart transplantation; chagas cardiomyopathy; chagas ... See more keywords
Heart transplant outcomes in patients with Chagas cardiomyopathy in the United States
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DOI: 10.1111/ctr.13279
Abstract: Chagas cardiomyopathy (CC) is one of the chronic manifestations of Trypanosoma cruzi (T. cruzi) infection and is among the leading reasons for heart transplantation (HT) in Latin America. Chagas disease is also present in areas… read more here.
Keywords: outcomes patients; heart transplant; united states; chagas cardiomyopathy ... See more keywords
Echocardiographic parameters, speckle tracking, and brain natriuretic peptide levels as indicators of progression of indeterminate stage to Chagas cardiomyopathy
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DOI: 10.1111/echo.14603
Abstract: Chronic Chagas cardiomyopathy (CCM) is characterized by a unique type of cardiac involvement. Few studies have characterized echocardiographic (Echo) transitions from the indeterminate Chagas disease (ChD) form to CCM. The objective of this study was… read more here.
Keywords: natriuretic peptide; speckle tracking; chagas cardiomyopathy; parameters speckle ... See more keywords
Antiparasitic treatment with itraconazole and amiodarone in 2 dogs with severe, symptomatic Chagas cardiomyopathy
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DOI: 10.1111/jvim.16422
Abstract: Abstract Chagas cardiomyopathy, caused by the protozoal parasite Trypanosoma cruzi, is characterized by arrhythmias, myocardial damage, heart failure, and sudden death. We describe 2 dogs with severe, symptomatic Chagas cardiomyopathy characterized by myocardial dysfunction and… read more here.
Keywords: dogs severe; severe symptomatic; chagas cardiomyopathy; antiparasitic treatment ... See more keywords
GWAS loci associated with Chagas cardiomyopathy influences DNA methylation levels
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DOI: 10.1371/journal.pntd.0009874
Abstract: A recent genome-wide association study (GWAS) identified a locus in chromosome 11 associated with the chronic cardiac form of Chagas disease. Here we aimed to elucidate the potential functional mechanism underlying this genetic association by… read more here.
Keywords: cis; methylation; chagas; chagas cardiomyopathy ... See more keywords
Genome-wide association study for Chagas Cardiomyopathy identify a new risk locus on chromosome 18 associated with an immune-related protein and transcriptional signature
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DOI: 10.1371/journal.pntd.0010725
Abstract: Background Chronic Chagas Cardiomyopathy (CCC) usually develops between 10 and 20 years after the first parasitic infection and is one of the leading causes of end-stage heart failure in Latin America. Despite the great inter-individual… read more here.
Keywords: locus; signature; chagas cardiomyopathy; immune related ... See more keywords
Exercise tests in Chagas cardiomyopathy: an overview of functional evaluation, prognostic significance, and current challenges
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DOI: 10.1590/0037-8682-0100-2020
Abstract: Abstract Patients with Chagas cardiomyopathy (ChC) usually progress with fatigue and dyspnea. Exercise tests are valuable for the functional evaluation of these patients. However, information about the applicability of the exercise tests is scattered, and… read more here.
Keywords: functional evaluation; exercise tests; chagas cardiomyopathy; exercise ... See more keywords
Chronic Chagas Cardiomyopathy Patients and Resynchronization Therapy: a Survival Analysis
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DOI: 10.21470/1678-9741-2017-0134
Abstract: Introduction Chagas disease represents an important health problem with socioeconomic impacts in many Latin-American countries. It is estimated that 20% to 30% of the people infected by Trypanosoma cruzi will develop chronic Chagas cardiomyopathy (CCC),… read more here.
Keywords: chagas; resynchronization therapy; chagas cardiomyopathy; chronic chagas ... See more keywords
Treatment With Suboptimal Dose of Benznidazole Mitigates Immune Response Molecular Pathways in Mice With Chronic Chagas Cardiomyopathy
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DOI: 10.3389/fcimb.2021.692655
Abstract: Chronic Chagas cardiomyopathy (CCC) is the most frequent and severe form of Chagas disease, a neglected tropical illness caused by the protozoan Trypanosoma cruzi, and the main cause of morbimortality from cardiovascular problems in endemic… read more here.
Keywords: ccc; response; immune response; chagas cardiomyopathy ... See more keywords
Modulation of Regulatory T Cells Activity by Distinct CD80 and CD86 Interactions With CD28/CTLA-4 in Chagas Cardiomyopathy
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DOI: 10.3389/fcvm.2022.750876
Abstract: Chagas cardiomyopathy is the symptomatic cardiac clinical form (CARD) of the chronic phase of Chagas disease caused by Trypanosoma cruzi infection. It was described as the most fibrosing cardiomyopathies, affecting approximately 30% of patients during… read more here.
Keywords: cd80 cd86; treg; cd80; chagas cardiomyopathy ... See more keywords
Diffuse Myocardial Fibrosis and Cardiomyocyte Diameter Are Associated With Heart Failure Symptoms in Chagas Cardiomyopathy
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DOI: 10.3389/fcvm.2022.880151
Abstract: Background Chronic Chagas cardiomyopathy (CCC) constitutes the most life-threatening consequence of the Trypanosoma cruzi infection. Our goal was to test in CCC the associations of the myocardial tissue phenotype with cardiac dysfunction, and heart failure… read more here.
Keywords: heart failure; chagas cardiomyopathy; heart; cardiomyocyte diameter ... See more keywords