Risk of Chronic Cardiomyopathy Among Patients With the Acute Phase or Indeterminate Form of Chagas Disease
Sign Up to like & getrecommendations! Published in 2020 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2020.15072
Abstract: Key Points Question What is the risk of developing cardiomyopathy among patients with the acute phase of Chagas infection or the indeterminate chronic form of Chagas disease? Findings In this systematic review and meta-analysis of… read more here.
Keywords: among patients; patients acute; chagas; cardiomyopathy among ... See more keywords
Biopharmaceutical Characteristics of Nifurtimox Tablets for Age‐ and Body Weight‐Adjusted Dosing in Patients With Chagas Disease
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.871
Abstract: Treatment of Chagas disease with nifurtimox requires age‐ and body weight‐adjusted dosing, resulting in complex dosing instructions. Appropriate formulations are needed for precise and compliant dosing, especially in pediatric patients. We characterized the biopharmaceutical features… read more here.
Keywords: auc0 tlast; age body; adjusted dosing; weight adjusted ... See more keywords
Muscle mass, muscle strength, and functional capacity in patients with heart failure of Chagas disease and other aetiologies
Sign Up to like & getrecommendations! Published in 2020 at "ESC Heart Failure"
DOI: 10.1002/ehf2.12936
Abstract: Patients with Chagas disease and heart failure (HF) have a poor prognosis similar to that of patients with ischaemic or dilated cardiomyopathy. However, the impact of body composition and muscle strength changes in these aetiologies… read more here.
Keywords: muscle strength; heart; chagas disease; heart failure ... See more keywords
Assessing Parasite Load in Chagas Disease Patients by Quantitative Multiplex Real-Time PCR.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9148-8_16
Abstract: The development of accurate diagnostic tools and surrogate markers of parasitological response to treatment are priorities in Chagas disease (CD) research. For years, the detection of Trypanosoma cruzi DNA by PCR has proved to be… read more here.
Keywords: real time; time pcr; pcr; load ... See more keywords
Chagas disease reactivation in rheumatologic patients: association with immunosuppressive therapy and humoral response
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Rheumatology"
DOI: 10.1007/s10067-021-05581-2
Abstract: Evidence for Chagas disease reactivation (CDR) in rheumatologic patients under rheumatologic treatments (RTs) is scarce. To screen and follow-up patients with rheumatic diseases and concomitant Chagas disease under RT to detect CDR and to describe… read more here.
Keywords: cdr; disease reactivation; chagas disease; disease ... See more keywords
Chagas disease: modulation of the inflammatory response by acetylcholinesterase in hematological cells and brain tissue
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-3113-y
Abstract: Chagas disease is an acute or chronic illness that causes severe inflammatory response, and consequently, it may activate the inflammatory cholinergic pathway, which is regulated by cholinesterases, including the acetylcholinesterase. This enzyme is responsible for… read more here.
Keywords: acetylcholinesterase; response; inflammatory response; brain ... See more keywords
Metabolomics, lipidomics and proteomics profiling of myoblasts infected with Trypanosoma cruzi after treatment with different drugs against Chagas disease
Sign Up to like & getrecommendations! Published in 2019 at "Metabolomics"
DOI: 10.1007/s11306-019-1583-5
Abstract: Chagas disease, the most important parasitic infection in Latin America, is caused by the intracellular protozoan Trypanosoma cruzi. To treat this disease, only two nitroheterocyclic compounds with toxic side effects exist and frequent treatment failures… read more here.
Keywords: disease; drug; cruzi; host ... See more keywords
Variation in the Mitochondrial Genome of the Chagas Disease Vector Triatoma infestans (Hemiptera: Reduviidae).
Sign Up to like & getrecommendations! Published in 2022 at "Neotropical entomology"
DOI: 10.1007/s13744-022-00953-y
Abstract: Chagas' disease is transmitted mainly by members of the subfamily Triatominae (Hemiptera: Reduviidae). Among them, Triatoma infestans (Klug) is the main vector of the disease in Southern Cone of Latin America. In order to contribute… read more here.
Keywords: chagas disease; hemiptera reduviidae; disease; triatoma infestans ... See more keywords
Trypanosoma cruzi genetic diversity: Something new for something known about Chagas disease manifestations, serodiagnosis and drug sensitivity.
Sign Up to like & getrecommendations! Published in 2018 at "Acta tropica"
DOI: 10.1016/j.actatropica.2017.09.017
Abstract: The genetic diversity of Trypanosoma cruzi, the protozoan agent of Chagas disease, is widely recognized. At present, T. cruzi is partitioned into seven discrete typing units (DTUs), TcI-TcVI and Tcbat. This article reviews the present… read more here.
Keywords: genetic diversity; something; cruzi; trypanosoma cruzi ... See more keywords
Reproductive aspects of Chagas disease vectors (Hemiptera, Triatominae) with anatomical teratologies.
Sign Up to like & getrecommendations! Published in 2018 at "Acta tropica"
DOI: 10.1016/j.actatropica.2018.05.022
Abstract: As Chagas disease has no cure, vector control is the most effective method of preventing this neglected disease. Generally the anatomical teratologies are associated with hormonal dysfunction of the corpus allatum (juvenile hormone), presents genetic… read more here.
Keywords: disease vectors; reproductive aspects; aspects chagas; disease ... See more keywords
Role of Nucleic Acid Amplification assays in monitoring treatment response in Chagas disease: Usefulness in clinical trials.
Sign Up to like & getrecommendations! Published in 2019 at "Acta tropica"
DOI: 10.1016/j.actatropica.2019.105120
Abstract: Chagas disease has become a global health problem due to migration of infected people out of Latin America to non-endemic countries. For more than 40 years, only the nitroimidazole compounds Benznidazole and Nifurtimox, have been… read more here.
Keywords: chagas disease; treatment; response; clinical trials ... See more keywords