Decreased long-chain acylcarnitines from insufficient β-oxidation as potential early diagnostic markers for Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-06767-y
Abstract: Increasing evidence shows that metabolic abnormalities in body fluids are distinguishing features of the pathophysiology of Parkinson’s disease. However, a non-invasive approach has not been established in the earliest or pre-symptomatic phases. Here, we report… read more here.
Keywords: long chain; chain acylcarnitines; oxidation; parkinson disease ... See more keywords
Plasma acylcarnitines are associated with pulmonary hypertension
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DOI: 10.1086/690554
Abstract: Quantifying metabolic derangements in pulmonary hypertension (PH) by plasma metabolomics could identify biomarkers useful for diagnosis and treatment. The objective of this paper is to test the hypotheses that circulating metabolites are differentially expressed in… read more here.
Keywords: hypertension plasma; pulmonary hypertension; compared controls; hypertension ... See more keywords
Long-Chain Acylcarnitines and Cardiac Excitation-Contraction Coupling: Links to Arrhythmias
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DOI: 10.3389/fphys.2020.577856
Abstract: A growing number of metabolomic studies have associated high circulating levels of the amphiphilic fatty acid metabolites, long-chain acylcarnitines (LCACs), with cardiovascular disease (CVD) risk. These studies show that plasma LCAC levels can be correlated… read more here.
Keywords: contraction coupling; cardiac excitation; long chain; chain acylcarnitines ... See more keywords