Escaping from the Cutoff Paradox by Accumulating Long-Chain Alcohols in the Cell Membrane.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00629
Abstract: The mechanism for the cutoff, an activity cliff at which long-chain alcohols lose their biological effects, has not been elucidated. Highly hydrophobic oleyl alcohol (C18:1) exists as a mixture of monomers and aggregated droplets in… read more here.
Keywords: long chain; chain alcohols; escaping cutoff; membrane ... See more keywords
A Comparative Ab Initio Study of Anhydrous Dehydrogenation of Linear-Chain Alcohols on Cu(110)
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Physical Chemistry C"
DOI: 10.1021/acs.jpcc.8b01698
Abstract: The catalytic behavior of Cu surfaces in the anhydrous production of aldehydes from alcohols, a process of industrial significance, is puzzling: the two simplest alcohols (methanol and ethanol) show dramatically different decomposition behavior on Cu.… read more here.
Keywords: chain; dehydrogenation; dehydrogenation linear; anhydrous dehydrogenation ... See more keywords
Profiling the short-lived cationic species generated during catalytic dehydration of short-chain alcohols
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DOI: 10.1038/s42004-018-0053-8
Abstract: Short-chain alcohols are important products of biomass conversion and can be further converted into platform chemicals via catalytic dehydration. Although cationic species are believed to be intermediates in the alcohol-to-hydrocarbon processes, directly observing them is… read more here.
Keywords: cationic species; short chain; chain alcohols; dehydration ... See more keywords
Evolutionary engineering improves tolerance for medium-chain alcohols in Saccharomyces cerevisiae
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology for Biofuels"
DOI: 10.1186/s13068-018-1089-9
Abstract: BackgroundYeast-based chemical production is an environmentally friendly alternative to petroleum-based production or processes that involve harsh chemicals. However, many potential alcohol biofuels, such as n-butanol, isobutanol and n-hexanol, are toxic to production organisms, lowering the… read more here.
Keywords: tolerance; medium chain; chain alcohols; saccharomyces cerevisiae ... See more keywords
A Pseudomonas putida efflux pump acts on short-chain alcohols
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology for Biofuels"
DOI: 10.1186/s13068-018-1133-9
Abstract: BackgroundThe microbial production of biofuels is complicated by a tradeoff between yield and toxicity of many fuels. Efflux pumps enable bacteria to tolerate toxic substances by their removal from the cells while bypassing the periplasm.… read more here.
Keywords: pump; chain alcohols; short chain; efflux pump ... See more keywords