Structure and energetics of ligand-fluorine interactions with galectin-3 backbone and side-chain amides - insight into solvation effects and multipolar interactions.
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DOI: 10.2210/pdb6qlo/pdb
Abstract: Multipolar fluorine–amide interactions with backbone and side-chain amides have been described as important for protein–ligand interactions and have been used to improve the potency of synthetic inhibitors. In this study, fluorine interactions within a well-defined… read more here.
Keywords: chain; amide interactions; chain amides; backbone side ... See more keywords