Mechanism and Inhibitor Exploration with Binuclear Mg Ketol‐Acid Reductoisomerase: Targeting the Biosynthetic Pathway of Branched‐Chain Amino Acids
Sign Up to like & getrecommendations! Published in 2019 at "ChemBioChem"
DOI: 10.1002/cbic.201900363
Abstract: Binuclear Mg ketol‐acid reductoisomerase (KARI), which converts (S)‐2‐acetolactate into (R)‐2,3‐dihydroxyisovalerate, is responsible for the second step of the biosynthesis of branched‐chain amino acids in plants and microorganisms and thus serves as a key inhibition target… read more here.
Keywords: binuclear ketol; mechanism; chain amino; branched chain ... See more keywords
Circulating branched‐chain amino acids and incident heart failure in type 2 diabetes: The Hong Kong Diabetes Register
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.3253
Abstract: Levels of branched‐chain amino acids (BCAAs, namely, isoleucine, leucine, and valine) are modulated by dietary intake and metabolic/genetic factors. BCAAs are associated with insulin resistance and increased risk of type 2 diabetes (T2D). Although insulin… read more here.
Keywords: amino acids; chain amino; heart failure; branched chain ... See more keywords
Overview of chromatographic and electrophoretic methods for the determination of branched-chain amino acids.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of separation science"
DOI: 10.1002/jssc.202300213
Abstract: The significance of branched-chain amino acids in diseases was clearly shown over the years. This review aims to describe the available techniques for their analytical determination. The article provides examples of the use of various… read more here.
Keywords: determination; amino acids; chain amino; branched chain ... See more keywords
Branched‐chain amino acid supplementation impairs insulin sensitivity and promotes lipogenesis during exercise in diet‐induced obese mice
Sign Up to like & getrecommendations! Published in 2022 at "Obesity"
DOI: 10.1002/oby.23394
Abstract: Branched‐chain amino acids (BCAAs) are popular dietary supplements for exercise. However, increased BCAA levels positively correlate with obesity and diabetes. The metabolic impact of BCAA supplementation on insulin sensitivity during exercise is less understood. read more here.
Keywords: supplementation; chain amino; insulin sensitivity; branched chain ... See more keywords
Enhanced cerebral branched-chain amino acid metabolism in R6/2 mouse model of Huntington’s disease
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03051-2
Abstract: Huntington’s disease (HD) is a hereditary and fatal disease causing profound neurodegeneration. Deficits in cerebral energy and neurotransmitter metabolism have been suggested to play a central role in the neuronal dysfunction and death associated with… read more here.
Keywords: isoleucine; metabolism; huntington disease; chain amino ... See more keywords
Branched Chain Amino Acids in Metabolic Disease
Sign Up to like & getrecommendations! Published in 2018 at "Current Diabetes Reports"
DOI: 10.1007/s11892-018-1048-7
Abstract: Purpose of ReviewElevations in circulating branched chain amino acids (BCAAs) have gained attention as potential contributors to the development of insulin resistance and diabetes.Recent FindingsEpidemiological evidence strongly supports this conclusion. Suppression of BCAA catabolism in… read more here.
Keywords: branched chain; amino acids; chain amino; insulin resistance ... See more keywords
Lipoprotein insulin resistance score and branched-chain amino acids increase after adrenalectomy for unilateral aldosterone-producing adenoma: a preliminary study
Sign Up to like & getrecommendations! Published in 2020 at "Endocrine"
DOI: 10.1007/s12020-020-02235-2
Abstract: Background and aims Primary aldosteronism (PA) due to unilateral aldosterone-producing adenoma (APA) is preferentially treated by unilateral adrenalectomy (ADX), but little is known about the changes in lipid and glucose metabolism that may occur after… read more here.
Keywords: amino acids; chain amino; producing adenoma; aldosterone producing ... See more keywords
Effect of Oral Branched-Chain Amino Acids on Serum Albumin Concentration in Heart Failure Patients with Hypoalbuminemia: Results of a Preliminary Study
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Cardiovascular Drugs"
DOI: 10.1007/s40256-018-0269-0
Abstract: BackgroundWe conducted a randomized, controlled trial to determine whether supplementation with oral branched-chain amino acids (BCAAs) improves serum albumin and clinical outcomes in heart failure (HF) patients with hypoalbuminemia.Methods and resultsWe randomly assigned 18 in-hospital… read more here.
Keywords: oral branched; amino acids; chain amino; branched chain ... See more keywords
Branched-Chain Amino Acids and Seizures: A Systematic Review of the Literature
Sign Up to like & getrecommendations! Published in 2019 at "CNS Drugs"
DOI: 10.1007/s40263-019-00650-2
Abstract: Up to 40% of patients with epilepsy experience seizures despite treatment with antiepileptic drugs; however, branched-chain amino acid (BCAA) supplementation has shown promise in treating refractory epilepsy. The purpose of this systematic review was to… read more here.
Keywords: branched chain; one study; seizure; chain amino ... See more keywords
Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.10.082
Abstract: Foxp3+ regulatory T (Treg) cells, which suppress immune responses, are highly proliferative in vivo. However, it remains unclear how the active replication of Treg cells is maintained in vivo. Here, we show that branched-chain amino acids (BCAAs),… read more here.
Keywords: treg cells; maintenance; chain amino; branched chain ... See more keywords
A novel NMR-based assay to measure circulating concentrations of branched-chain amino acids: Elevation in subjects with type 2 diabetes mellitus and association with carotid intima media thickness.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical biochemistry"
DOI: 10.1016/j.clinbiochem.2018.02.001
Abstract: OBJECTIVES Plasma branched-chain amino acid (BCAA) levels, measured on nuclear magnetic resonance (NMR) metabolomics research platforms or by mass spectrometry, have been shown to be associated with type 2 diabetes mellitus (T2DM) and cardiovascular disease… read more here.
Keywords: chain amino; branched chain; type diabetes; diabetes mellitus ... See more keywords