Evidence of a skewed T‐cell repertoire in patients with light chain amyloidosis
Sign Up to like & getrecommendations! Published in 2018 at "Hematological Oncology"
DOI: 10.1002/hon.2281
Abstract: Keywords: light-chain amyloidosis; T-cell receptor repertoire; regulatory T-cells; flow cytometry; spectratyping; CDR3 read more here.
Keywords: repertoire; cell; chain amyloidosis; light chain ... See more keywords
Population Pharmacokinetics and Exposure-Response Modeling of Daratumumab Subcutaneous Administration in Patients With Light-chain Amyloidosis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of clinical pharmacology"
DOI: 10.1002/jcph.1994
Abstract: The purpose of this study is to characterize the population pharmacokinetics (PopPK) of subcutaneous (SC) daratumumab in combination with bortezomib, cyclophosphamide, and dexamethasone and explore the relationship between daratumumab systemic exposure and selected efficacy and… read more here.
Keywords: analysis; chain amyloidosis; response; light chain ... See more keywords
Development of a conceptual model of patient-reported outcomes in light chain amyloidosis: a qualitative study
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DOI: 10.1007/s11136-021-02943-w
Abstract: Light chain (AL) amyloidosis is a plasma cell neoplasm associated with high early mortality and severe morbidity that can cause severe disability. We explored the impact of AL amyloidosis on symptoms and well-being from the… read more here.
Keywords: reported outcomes; chain amyloidosis; amyloidosis; light chain ... See more keywords
Focused review on nutritional status of patients with immunoglobulin light chain amyloidosis.
Sign Up to like & getrecommendations! Published in 2022 at "Current problems in cancer"
DOI: 10.1016/j.currproblcancer.2021.100833
Abstract: BACKGROUND Immunoglobulin light chain (AL) amyloidosis is a complex disease marked by a poor clinical portrait and prognosis generally leading to organ dysfunction and shortened survival. We aimed to review the available evidence on whether… read more here.
Keywords: light chain; chain amyloidosis; immunoglobulin light; nutritional status ... See more keywords
Novel Therapies in Light Chain Amyloidosis
Sign Up to like & getrecommendations! Published in 2018 at "Kidney International Reports"
DOI: 10.1016/j.ekir.2017.11.017
Abstract: Light chain (AL) amyloidosis is the most common form of amyloidosis involving the kidney. It is characterized by albuminuria, progressing to overt nephrotic syndrome and eventually end-stage renal failure if diagnosed late or ineffectively treated,… read more here.
Keywords: risk; chain amyloidosis; amyloidosis; light chain ... See more keywords
Acquired factor X deficiency in light-chain (AL) amyloidosis is rare and associated with advanced disease.
Sign Up to like & getrecommendations! Published in 2019 at "Hematology/oncology and stem cell therapy"
DOI: 10.1016/j.hemonc.2018.05.002
Abstract: INTRODUCTION Systemic light chain (AL) amyloidosis can lead to an acquired coagulopathy secondary to acquired factor X (aFX) deficiency. However, it is not very clear who develops aFX deficiency in AL amyloidosis. METHODS We therefore… read more here.
Keywords: chain amyloidosis; light chain; deficiency; afx deficiency ... See more keywords
Therapies for cardiac light chain amyloidosis: An update.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2018.05.018
Abstract: Light-chain (AL) amyloidosis is the most common type of systemic amyloidosis, affecting around 10 people per million per year. This serious disorder is characterized by the presence of a clone of bone marrow plasma cells… read more here.
Keywords: chain amyloidosis; therapies cardiac; light; amyloidosis ... See more keywords
Coagulation Abnormalities in Light Chain Amyloidosis.
Sign Up to like & getrecommendations! Published in 2021 at "Mayo Clinic proceedings"
DOI: 10.1016/j.mayocp.2020.06.061
Abstract: OBJECTIVE To assess the prevalence of coagulation abnormalities in patients with systemic light chain (AL) amyloidosis and their association with disease-related characteristics, disease progression, and survival. PATIENTS AND METHODS This is a retrospective study of… read more here.
Keywords: coagulation; chain amyloidosis; coagulation abnormalities; light chain ... See more keywords
Changes in patient-reported outcomes in light chain amyloidosis in the first year after diagnosis and relationship to NT-proBNP change
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DOI: 10.1038/s41408-021-00412-8
Abstract: We conducted a prospective cohort study in newly diagnosed systemic light chain (AL) amyloidosis patients ( N = 59) to study patient-reported outcomes (PROs) through the first year. The median age was 68 years with 42%… read more here.
Keywords: reported outcomes; chain amyloidosis; first year; year ... See more keywords
Racial disparities in patients diagnosed with light chain (AL) amyloidosis
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DOI: 10.1038/s41408-021-00466-8
Abstract: Dear Editor, Light chain (AL) amyloidosis arises from a precursor plasma cell neoplasm that produces clonal free light chains that form insoluble fibril deposits leading to organ dysfunction. Because the disease is rare, heterogeneous, and… read more here.
Keywords: chain amyloidosis; diagnosis; amyloidosis; light chain ... See more keywords
Immunoglobulin light chain amyloidosis diagnosis and treatment algorithm 2021
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DOI: 10.1038/s41408-021-00483-7
Abstract: Immunoglobulin light chain amyloidosis (AL) commonly presents with nephrotic range proteinuria, heart failure with preserved ejection fraction, nondiabetic peripheral neuropathy, unexplained hepatomegaly or diarrhea, and should be considered in patients presenting with these symptoms. More… read more here.
Keywords: immunoglobulin light; amyloidosis; chain amyloidosis; light chain ... See more keywords