Synthesis of single‐chain antibody fragment fused to the elastin‐like polypeptide in Nicotiana benthamiana and its application in affinity precipitation of difficult to produce proteins
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28158
Abstract: Plants are economical and sustainable factories for the production of recombinant proteins. Currently, numerous proteins produced using different plant‐based systems with applications as cosmetic and tissue culture ingredients, research and diagnostic reagents, and industrial enzymes… read more here.
Keywords: elp; elastin like; single chain; chain antibody ... See more keywords
Bovine single chain Fv antibody inhibits bovine herpesvirus-1 infectivity by targeting viral glycoprotein D
Sign Up to like & getrecommendations! Published in 2017 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-017-8566-0
Abstract: Glycoprotein D (gD) of bovine herpesvirus-1 (BoHV-1) is essential for attachment and penetration of cells during infection and is a major target for neutralizing antibodies during an adaptive immune response. Currently there are no recombinant… read more here.
Keywords: chain antibody; bovine; bovine herpesvirus; bohv ... See more keywords
Detection of Free Prostate-Specific Antigen Using a Novel Single-Chain Antibody (scAb)-Based Magneto-Immunosensor
Sign Up to like & getrecommendations! Published in 2018 at "BioNanoScience"
DOI: 10.1007/s12668-017-0394-2
Abstract: The proportion of prostate-specific antigen (PSA) circulating in the free form can help to differentiate prostate cancer from benign prostate disease. In this paper, novel highly specific single-chain antibody (scAb) fragments were conjugated to magnetic… read more here.
Keywords: prostate; chain antibody; prostate specific; antibody ... See more keywords
CAR T-cell bioengineering: Single variable domain of heavy chain antibody targeted CARs.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced drug delivery reviews"
DOI: 10.1016/j.addr.2019.04.006
Abstract: Redirecting the recognition specificity of T lymphocytes to designated tumour cell surface antigens by transferring chimeric antigen receptor (CAR) genes is becoming an effective strategy to combat cancer. Today, CAR T-cell therapy has proven successful… read more here.
Keywords: car cell; chain antibody; cell; car ... See more keywords
A Recombinant Antibody-Expressing Influenza Virus Delays Tumor Growth in a Mouse Model.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2017.12.025
Abstract: Influenza A virus (IAV) has shown promise as an oncolytic agent. To improve IAV as an oncolytic virus, we sought to design a transgenic virus expressing an immune checkpoint-inhibiting antibody during the viral life cycle.… read more here.
Keywords: chain antibody; antibody; influenza virus; growth ... See more keywords
Construction of an immunized rabbit phage display antibody library for screening microcystin-LR high sensitive single-chain antibody.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.11.122
Abstract: Microcystin-LR (MC-LR) is one of the most common biotoxin that pollutes water and agricultural products. The study aims to obtain the high sensitive anti-MC-LR single-chain antibody (scFv) for detecting MC-LR. Here, a MC-LR-immunized rabbit phage… read more here.
Keywords: high sensitive; chain antibody; immunized rabbit; phage ... See more keywords
Site-Specific Modification of Single-Chain Antibody Fragments for Bioconjugation and Vascular Immunotargeting.
Sign Up to like & getrecommendations! Published in 2018 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.7b00592
Abstract: The conjugation of antibodies to drugs and drug carriers improves delivery to target tissues. Widespread implementation and effective translation of this pharmacologic strategy awaits the development of affinity ligands capable of a defined degree of… read more here.
Keywords: chain antibody; site specific; chemistry; modification ... See more keywords
An anti-CTLA-4 heavy chain–only antibody with enhanced Treg depletion shows excellent preclinical efficacy and safety profile
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2200879119
Abstract: Significance This article describes a fully human therapeutic heavy chain–only antibody for anti-tumor treatment. We show that this anti-CTLA-4 antibody, HCAb 4003-2, has advantageous properties and stimulates anti-tumor T cell activation in several ways: 1)… read more here.
Keywords: anti ctla; heavy chain; chain antibody; tumor ... See more keywords
Construction and preliminary identification of a prokaryotic expression single-chain antibody fragments library against Streptococcus pneumoniae from antibody-producing cells in human tonsil
Sign Up to like & getrecommendations! Published in 2019 at "Bioengineered"
DOI: 10.1080/21655979.2019.1616492
Abstract: ABSTRACT Tonsillitis is the inflammation of the tonsils due to infection, many patients ultimately have to undergo tonsillectomy. In order to improve the accuracy of diagnosis and even create a new treatment for tonsillitis, we… read more here.
Keywords: chain; chain antibody; pneumoniae; antibody ... See more keywords
Combined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse model
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DOI: 10.1093/brain/awx052
Abstract: One of the greatest challenges for the treatment of neurodegenerative disease is crossing the blood-brain barrier. Nisbet et al. demonstrate that non-invasive scanning ultrasound increases the delivery of tau-specific single-chain antibody fragments across the blood-brain… read more here.
Keywords: tau; chain antibody; tau specific; scanning ultrasound ... See more keywords
Single-chain antibody–delivered Livin siRNA inhibits human malignant melanoma growth in vitro and in vivo
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DOI: 10.1177/1010428317701645
Abstract: Although gene therapy has brought new insights into the treatment of malignant melanoma, targeting delivery of nucleic acid which targets critical oncogene/anti-oncogene in vivo is still a bottleneck in the therapeutic application. Our previous in… read more here.
Keywords: melanoma; chain antibody; small interfering; interfering rna ... See more keywords