Antibody homotypic interactions are encoded by germline light chain complementarity determining region 2
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2201562119
Abstract: Significance Weak transient interactions are fundamental to immune responses, enabling avidity-driven triggers for pathogen neutralization and cellular regulation. In contrast to obligate binding interactions that can be directly investigated structurally, the low or transitory abundance… read more here.
Keywords: complementarity determining; light chain; homotypic; germline light ... See more keywords
Joined at the hip: The role of light chain complementarity determining region 2 in antibody self-association
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DOI: 10.1073/pnas.2208330119
Abstract: The amplification of weak transient protein–protein interactions to elicit robust immune responses is a recurring theme in immune processes (1) (Fig. 1). Given the often highly repetitive nature of pathogenic targets, antibodies have evolved architectures… read more here.
Keywords: self association; chain complementarity; homotypic interactions; antibody self ... See more keywords