Microbial production of odd‐chain fatty acids
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28308
Abstract: Odd‐chain fatty acids (OcFAs) and their derivatives have attracted much attention due to their beneficial physiological effects and their potential to be alternatives to advanced fuels. However, cells naturally produce even‐chain fatty acids (EcFAs) with… read more here.
Keywords: chain fatty; production; odd chain; fatty acids ... See more keywords
The Pharmacokinetics of Triheptanoin and Its Metabolites in Healthy Subjects and Patients With Long-Chain Fatty Acid Oxidation Disorders.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical pharmacology in drug development"
DOI: 10.1002/cpdd.944
Abstract: Long-chain fatty acid oxidation disorders (LC-FAODs) are a group of life-threatening autosomal recessive disorders caused by defects in nuclear genes encoding mitochondrial enzymes involved in the conversion of dietary long-chain fatty acids into energy. Triheptanoin… read more here.
Keywords: chain; triheptanoin metabolites; fatty acid; long chain ... See more keywords
Discovery and identification of medium‐chain fatty acid responsive promoters in Saccharomyces cerevisiae
Sign Up to like & getrecommendations! Published in 2020 at "Engineering in Life Sciences"
DOI: 10.1002/elsc.201900093
Abstract: Medium‐chain fatty acids (MCFAs) and their derivatives are important chemicals that can be used in lubricants, detergents, and cosmetics. MCFAs can be produced in several microbes, although production is not high. Dynamic regulation by synthetic… read more here.
Keywords: saccharomyces cerevisiae; fatty acid; responsive promoters; medium chain ... See more keywords
Drug discovery for X‐linked adrenoleukodystrophy: An unbiased screen for compounds that lower very long‐chain fatty acids
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30014
Abstract: X‐linked adrenoleukodystrophy (XALD) is a genetic neurologic disorder with multiple phenotypic presentations and limited therapeutic options. The childhood cerebral phenotype (CCALD), a fatal demyelinating disorder affecting about 35% of patients, and the adult‐onset adrenomyeloneuropathy (AMN),… read more here.
Keywords: c26; linked adrenoleukodystrophy; fatty acids; drug ... See more keywords
Effects of triheptanoin (UX007) in patients with long‐chain fatty acid oxidation disorders: Results from an open‐label, long‐term extension study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12313
Abstract: Long‐chain fatty acid oxidation disorders (LC‐FAOD) are autosomal recessive conditions that impair conversion of long‐chain fatty acids into energy, leading to significant clinical symptoms. Triheptanoin is a highly purified, 7‐carbon chain triglyceride approved in the… read more here.
Keywords: chain; duration; study; long chain ... See more keywords
Medium branched chain fatty acids improve the profile of tricarboxylic acid cycle intermediates in mitochondrial fatty acid β-oxidation deficient cells: A comparative study.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of inherited metabolic disease"
DOI: 10.1002/jimd.12480
Abstract: Inherited errors of mitochondrial fatty acid β-oxidation (FAO) are life threatening, even with optimum care. FAO is the major source of energy for heart and is critical for skeletal muscles especially during physiologic stress. Clinical… read more here.
Keywords: chain; deficient; fatty acids; chain fatty ... See more keywords
Acidolysis of Phospholipids with Medium-Chain Fatty Acids over M-SBA-15 (M = Zn, Al) Silicas as Efficient Solid Catalysts.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.11832
Abstract: Efficient and sustainable production of structured phospholipids (SPLs) enriched in medium-chain fatty acids (MCFAs) in a heterogeneous manner is crucial for their potential applications in functional foods and drugs. Herein, for the first time, Zn… read more here.
Keywords: chain fatty; spectroscopy; sba silicas; fatty acids ... See more keywords
Hepatic and serum branched‐chain fatty acid profile in patients with nonalcoholic fatty liver disease: A case–control study
Sign Up to like & getrecommendations! Published in 2023 at "Obesity"
DOI: 10.1002/oby.23711
Abstract: Alterations in the hepatic lipidome are a crucial factor involved in the pathophysiology of nonalcoholic fatty liver disease (NAFLD). The aim of this study was to evaluate the serum and hepatic profile of branched‐chain fatty… read more here.
Keywords: nonalcoholic fatty; chain fatty; branched chain; fatty liver ... See more keywords
Assessment of AMPK-Stimulated Cellular Long-Chain Fatty Acid and Glucose Uptake.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7598-3_22
Abstract: Here we describe an assay for simultaneous measurement of cellular uptake rates of long-chain fatty acids (LCFA) and glucose that can be applied to cells in suspension. The uptake assay includes the use of radiolabeled… read more here.
Keywords: long chain; assessment ampk; lcfa glucose; chain fatty ... See more keywords
Development of a fast and cost-effective gas chromatography–mass spectrometry method for the quantification of short-chain and medium-chain fatty acids in human biofluids
Sign Up to like & getrecommendations! Published in 2017 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-017-0493-5
Abstract: The quantification of short-chain and medium-chain fatty acids is becoming more and more relevant in fecal and plasma samples due to their biological impact, which has been associated with colon rectal cancer and fiber consumption.… read more here.
Keywords: chain; method; medium chain; short chain ... See more keywords
Determination of long-chain fatty acids in anaerobic digester supernatant and olive mill wastewater exploiting an in-syringe dispersive liquid-liquid microextraction and derivatization-free GC-MS method
Sign Up to like & getrecommendations! Published in 2021 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-021-03338-z
Abstract: Long-chain fatty acids (LCFA) are commonly found in lipid-rich wastewaters and are a key factor to monitor the anaerobic digesters. A new simple, fast, precise, and suitable method for routine analysis of LCFA is proposed.… read more here.
Keywords: liquid; fatty acids; dispersive liquid; long chain ... See more keywords