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   Articles with "chain variable" as a keyword



Optimized Anti–Prostate‐Specific Membrane Antigen Single‐Chain Variable Fragment–Loaded Nanobubbles as a Novel Targeted Ultrasound Contrast Agent for the Diagnosis of Prostate Cancer

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recommendations! Published in 2019 at "Journal of Ultrasound in Medicine"

DOI: 10.1002/jum.15155

Abstract: To prepare optimized prostate‐specific membrane antigen (PSMA) single‐chain variable fragment (scFv)–loaded nanobubbles (NBs) as a novel targeted ultrasound (US) contrast agent for diagnosis and treatment of prostate cancer (PCa). read more here.

Keywords: prostate; prostate specific; specific membrane; chain variable ... See more keywords

Construction and characterization of a class-specific single-chain variable fragment against pyrethroid metabolites

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recommendations! Published in 2020 at "Applied Microbiology and Biotechnology"

DOI: 10.1007/s00253-020-10728-3

Abstract: Pyrethroids are insecticides that are widely used in rural and urban areas worldwide. After entering the environment, pyrethroids are rapidly metabolized or degraded by various biological or abiotic methods. In this study, a single-chain variable… read more here.

Keywords: pyrethroid metabolites; scfv; chain variable; variable fragment ... See more keywords

Expression of Single Chain Variable Fragment (scFv) Molecules in Plants: A Comprehensive Update

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recommendations! Published in 2020 at "Molecular Biotechnology"

DOI: 10.1007/s12033-020-00241-3

Abstract: Single chain variable fragments (scFvs) are generated by joining together the variable heavy and light chain of a monoclonal antibody (mAb) via a peptide linker. They offer some advantages over the parental mAb such as… read more here.

Keywords: chain; expression single; scfv; expression ... See more keywords
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Systematic engineering of optimized autonomous heavy-chain variable domains.

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recommendations! Published in 2021 at "Journal of molecular biology"

DOI: 10.1016/j.jmb.2021.167241

Abstract: Autonomous heavy-chain variable (VH) domains are the smallest functional antibody fragments, and they possess unique features, including small size and convex paratopes, which provide enhanced targeting of concave epitopes that are difficult to access with… read more here.

Keywords: chain; aggregation; heavy chain; variable domains ... See more keywords

Single chain variable fragment antibodies directed against SOD1 ameliorate disease in mutant SOD1 transgenic mice

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recommendations! Published in 2019 at "Neurobiology of Disease"

DOI: 10.1016/j.nbd.2018.08.021

Abstract: Mutations in Cu/Zn superoxide dismutase (SOD1) are the cause of ~20% of cases of familial ALS (FALS), which comprise ~10% of the overall total number of cases of ALS. Mutant (mt) SOD1 is thought to… read more here.

Keywords: sod1; directed sod1; mutant sod1; chain variable ... See more keywords

Anti-Aβ single-chain variable fragment antibodies restore memory acquisition in a Drosophila model of Alzheimer’s disease

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-11594-2

Abstract: Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder triggered by the accumulation of soluble assemblies of the amyloid-β42 (Aβ42) peptide. Despite remarkable advances in understanding the pathogenesis of AD, the development of palliative therapies is… read more here.

Keywords: drosophila; alzheimer disease; disease; chain variable ... See more keywords

Generation and functional characterization of a single-chain variable fragment (scFv) of the anti-FGF2 3F12E7 monoclonal antibody

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recommendations! Published in 2021 at "Scientific Reports"

DOI: 10.1038/s41598-020-80746-8

Abstract: Single-chain variable fragments (scFvs) are small-sized artificial constructs composed of the immunoglobulin heavy and light chain variable regions connected by a peptide linker. We have previously described an anti-fibroblast growth factor 2 (FGF2) immunoglobulin G… read more here.

Keywords: anti fgf2; scfv; chain variable; single chain ... See more keywords

Cross-neutralizing anti-HIV-1 human single chain variable fragments(scFvs) against CD4 binding site and N332 glycan identified from a recombinant phage library

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/srep45163

Abstract: More than 50% of HIV-1 infection globally is caused by subtype_C viruses. Majority of the broadly neutralizing antibodies (bnAbs) targeting HIV-1 have been isolated from non-subtype_C infected donors. Mapping the epitope specificities of bnAbs provides… read more here.

Keywords: phage; hiv; cross; cross neutralizing ... See more keywords

Engineered single chain variable fragments (scFvs) with improved pH-dependent kinetics for use in continuous biosensor applications

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recommendations! Published in 2025 at "RSC Advances"

DOI: 10.1039/d5ra02051d

Abstract: One challenge in the continuous monitoring of insulin lies with the unavailability of a high-affinity biological recognition element (BRE) with kinetic parameters sufficient to track fluctuating concentrations of insulin in vivo. An approach to overcome… read more here.

Keywords: chain variable; biosensor; insulin; single chain ... See more keywords

Development of single-chain Fv of antibody to DNA as intracellular delivery vehicle

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recommendations! Published in 2017 at "Animal Cells and Systems"

DOI: 10.1080/19768354.2017.1401556

Abstract: ABSTRACT Application of antibodies in most therapeutic area is limited to extracellular or membranous targets because of their impermeability of membrane. For the purpose of biotechnological and therapeutic application, developing intracellular localizing antibody is the… read more here.

Keywords: chain; vehicle; antibody; chain variable ... See more keywords

Generation of a Phage Display Chicken Single-Chain Variable Fragment Library.

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recommendations! Published in 2024 at "Cold Spring Harbor protocols"

DOI: 10.1101/pdb.prot108213

Abstract: Phage-displayed antibody fragment libraries can be constructed using essentially any species that is easily immunized, as long as the immunoglobulin variable region gene sequences are known. This protocol describes the procedures for the generation of… read more here.

Keywords: chain variable; phage; single chain; generation phage ... See more keywords