Optimized Anti–Prostate‐Specific Membrane Antigen Single‐Chain Variable Fragment–Loaded Nanobubbles as a Novel Targeted Ultrasound Contrast Agent for the Diagnosis of Prostate Cancer
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Ultrasound in Medicine"
DOI: 10.1002/jum.15155
Abstract: To prepare optimized prostate‐specific membrane antigen (PSMA) single‐chain variable fragment (scFv)–loaded nanobubbles (NBs) as a novel targeted ultrasound (US) contrast agent for diagnosis and treatment of prostate cancer (PCa). read more here.
Keywords: prostate; prostate specific; specific membrane; chain variable ... See more keywords
Construction and characterization of a class-specific single-chain variable fragment against pyrethroid metabolites
Sign Up to like & getrecommendations! Published in 2020 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-020-10728-3
Abstract: Pyrethroids are insecticides that are widely used in rural and urban areas worldwide. After entering the environment, pyrethroids are rapidly metabolized or degraded by various biological or abiotic methods. In this study, a single-chain variable… read more here.
Keywords: pyrethroid metabolites; scfv; chain variable; variable fragment ... See more keywords
Expression of Single Chain Variable Fragment (scFv) Molecules in Plants: A Comprehensive Update
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biotechnology"
DOI: 10.1007/s12033-020-00241-3
Abstract: Single chain variable fragments (scFvs) are generated by joining together the variable heavy and light chain of a monoclonal antibody (mAb) via a peptide linker. They offer some advantages over the parental mAb such as… read more here.
Keywords: chain; expression single; scfv; expression ... See more keywords
Systematic engineering of optimized autonomous heavy-chain variable domains.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2021.167241
Abstract: Autonomous heavy-chain variable (VH) domains are the smallest functional antibody fragments, and they possess unique features, including small size and convex paratopes, which provide enhanced targeting of concave epitopes that are difficult to access with… read more here.
Keywords: chain; aggregation; heavy chain; variable domains ... See more keywords
Single chain variable fragment antibodies directed against SOD1 ameliorate disease in mutant SOD1 transgenic mice
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2018.08.021
Abstract: Mutations in Cu/Zn superoxide dismutase (SOD1) are the cause of ~20% of cases of familial ALS (FALS), which comprise ~10% of the overall total number of cases of ALS. Mutant (mt) SOD1 is thought to… read more here.
Keywords: sod1; directed sod1; mutant sod1; chain variable ... See more keywords
Anti-Aβ single-chain variable fragment antibodies restore memory acquisition in a Drosophila model of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-11594-2
Abstract: Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder triggered by the accumulation of soluble assemblies of the amyloid-β42 (Aβ42) peptide. Despite remarkable advances in understanding the pathogenesis of AD, the development of palliative therapies is… read more here.
Keywords: drosophila; alzheimer disease; disease; chain variable ... See more keywords
Generation and functional characterization of a single-chain variable fragment (scFv) of the anti-FGF2 3F12E7 monoclonal antibody
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-020-80746-8
Abstract: Single-chain variable fragments (scFvs) are small-sized artificial constructs composed of the immunoglobulin heavy and light chain variable regions connected by a peptide linker. We have previously described an anti-fibroblast growth factor 2 (FGF2) immunoglobulin G… read more here.
Keywords: anti fgf2; scfv; chain variable; single chain ... See more keywords
Cross-neutralizing anti-HIV-1 human single chain variable fragments(scFvs) against CD4 binding site and N332 glycan identified from a recombinant phage library
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep45163
Abstract: More than 50% of HIV-1 infection globally is caused by subtype_C viruses. Majority of the broadly neutralizing antibodies (bnAbs) targeting HIV-1 have been isolated from non-subtype_C infected donors. Mapping the epitope specificities of bnAbs provides… read more here.
Keywords: phage; hiv; cross; cross neutralizing ... See more keywords
Development of single-chain Fv of antibody to DNA as intracellular delivery vehicle
Sign Up to like & getrecommendations! Published in 2017 at "Animal Cells and Systems"
DOI: 10.1080/19768354.2017.1401556
Abstract: ABSTRACT Application of antibodies in most therapeutic area is limited to extracellular or membranous targets because of their impermeability of membrane. For the purpose of biotechnological and therapeutic application, developing intracellular localizing antibody is the… read more here.
Keywords: chain; vehicle; antibody; chain variable ... See more keywords
T Cells Expressing Anti-B-Cell Maturation Antigen (BCMA) Chimeric Antigen Receptors with Antigen Recognition Domains Made up of Only Single Human Heavy Chain Variable Domains Specifically Recognize Bcma and Eradicate Tumors in Mice
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood.v130.suppl_1.504.504
Abstract: Multiple myeloma (MM) is an almost-always incurable malignancy of plasma cells. Chimeric antigen receptors (CARs) are artificial fusion proteins that incorporate antigen-recognition domains and T-cell signaling domains. CAR T cells have been shown to have… read more here.
Keywords: cells expressing; cd828z; antigen; chain variable ... See more keywords
A comprehensive comparison between camelid nanobodies and single chain variable fragments
Sign Up to like & getrecommendations! Published in 2021 at "Biomarker Research"
DOI: 10.1186/s40364-021-00332-6
Abstract: By the emergence of recombinant DNA technology, many antibody fragments have been developed devoid of undesired properties of natural immunoglobulins. Among them, camelid heavy-chain variable domains (VHHs) and single-chain variable fragments (scFvs) are the most… read more here.
Keywords: single chain; comprehensive comparison; chain; chain variable ... See more keywords