Chalcone Based Homodimeric PET Agent, 11C-(Chal)2DEA-Me, for Beta Amyloid Imaging: Synthesis and Bioevaluation.
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DOI: 10.1021/acs.molpharmaceut.7b01070
Abstract: Homodimeric chalcone based 11C-PET radiotracer, 11C-(Chal)2DEA-Me, was synthesized, and binding affinity toward beta amyloid (Aβ) was evaluated. The computational studies revealed multiple binding of the tracer at the recognition sites of Aβ fibrils. The bivalent… read more here.
Keywords: chal 2dea; 11c chal; beta amyloid; chalcone based ... See more keywords