Synthesis and Carbonic Anhydrase Inhibition of Tetrabromo Chalcone Derivatives
Sign Up to like & getrecommendations! Published in 2017 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201700198
Abstract: In the present study, human carbonic anhydrase (hCA) enzyme was purified and characterized from fresh blood human red cells by Sepharose‐4B‐l‐tyrosine‐sulfanilamide affinity gel chromatography. Secondly, a series of new tetrabromo chalcone derivatives containing 4,7‐methanoisoindol‐1,3‐dione (2a–i)… read more here.
Keywords: carbonic anhydrase; tetrabromo chalcone; chalcone derivatives; inhibition ... See more keywords
Mechanistic insights on DBU catalyzed β‐amination of nbs to chalcone driving by water: Multiple roles of water
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Computational Chemistry"
DOI: 10.1002/jcc.24700
Abstract: DFT calculations were conducted to pursue deeper understandings on the mechanism and the explicit role of trace water in the DBU‐catalyzed β‐amination of NBS to chalcone. Being different from previously proposed by Liang et al.,… read more here.
Keywords: nbs chalcone; water; dbu catalyzed; amination nbs ... See more keywords
Synthesis and evaluation of polyacrylamides derived from polycyclic pendant naphthalene, indole, and phenothiazine based chalcone moiety as potent antimicrobial agents
Sign Up to like & getrecommendations! Published in 2017 at "Polymers for Advanced Technologies"
DOI: 10.1002/pat.3972
Abstract: Polycyclic chalcone-containing polyacrylamides, namely, poly ((N-(4-((E)-3-(naphthalen-6-yl)-3-oxoprop-1-enyl) phenyl) acrylamide), poly((N-(4-((E)-3-(1H-indol-3-yl)-3-oxoprop-1-enyl) phenyl) acrylamide), and poly((N-(4-((E)-3-oxo-3-(10H-phenothiazin-8-yl) prop-1-enyl) phenyl) acrylamide), were synthesized by Claisen–Schmidt condensation reaction, followed by ultrasonic irradiation reduction. The synthesized polymers were characterized by Fourier transform… read more here.
Keywords: phenyl acrylamide; chalcone; enyl phenyl; oxoprop enyl ... See more keywords
Computational insight on the chalcone formation mechanism by the Claisen–Schmidt reaction
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Quantum Chemistry"
DOI: 10.1002/qua.25365
Abstract: New insight of the formation mechanism of chalcones is presented in the current study. Ab initio calculations were applied in studying the mechanistic pathways for the base-catalyzed Claisen–Schmidt condensation for obtaining chalcones (1,3-diphenyl-2-propen-1-ons). The energies… read more here.
Keywords: formation mechanism; mechanism; reaction; chalcone ... See more keywords
Synthesis, antibiotic modifying activity, ADMET study and molecular docking of chalcone (E)-3-(2,4-dichlorophenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one in strains of Staphylococcus aureus carrying MepA efflux pumps.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of microbiology"
DOI: 10.1007/s00203-021-02666-z
Abstract: The Staphylococcus aureus bacteria is a Gram-positive, immobile, non-spore bacterium, with catalase and positive coagulase, among other characteristics. It is responsible for important infections caused in the population and for hospital infections. Because of that… read more here.
Keywords: dichlorophenyl hydroxyphenyl; chalcone dichlorophenyl; hydroxyphenyl prop; chalcone ... See more keywords
Synthesis of Nitrogen Containing Chalcone: A Highly Sensitive and Selective Fluorescent Chemosensor for the Fe3+ Metal Ion in Aqueous Media
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Fluorescence"
DOI: 10.1007/s10895-020-02534-x
Abstract: Title compound (PTPO) was synthesized by the reaction of 2-acetyl pyridine with 3,4,5-trimethoxy benzaldehyde. The structure of the compound has been confirmed by spectroscopic techniques. Interaction of chalcone with different metal cations was analyzed based… read more here.
Keywords: metal; fluorescent chemosensor; chalcone; metal ion ... See more keywords
Mechanistic insights into the inhibition mechanism of cysteine cathepsins by chalcone-based inhibitors—a QM cluster model approach
Sign Up to like & getrecommendations! Published in 2019 at "Structural Chemistry"
DOI: 10.1007/s11224-018-1273-3
Abstract: Cathepsins are the most abundant cysteine proteases involved in many physiological processes. The imbalance between the natural cysteine protease inhibitors and cathepsins leads to many pathological conditions such as cancer, osteoporosis, and osteoarthritis. Thus, cysteine… read more here.
Keywords: cysteine; chalcone based; cysteine cathepsins; inhibition mechanism ... See more keywords
Biological perspective of a triazine derivative with isatin/chalcone/acridone: DFT and docking investigations
Sign Up to like & getrecommendations! Published in 2020 at "Structural Chemistry"
DOI: 10.1007/s11224-020-01609-6
Abstract: The article highlights insights into biological activity using computational methods in products of 1,3,5-triazine-2,4-diamine with 1H-indole-2,3-dione (isatin)/(2E)-13-diphenylprop-2-en-1-one (chalcone)/10H-acridin-9-one (acridone). Biological activity is carried out using the method of electron density, 6-311++G(d,p) for molecular and electronic… read more here.
Keywords: biological activity; isatin; biological perspective; acridone ... See more keywords
Tandem chalcone-sulfonamide hybridization, cyclization and further Claisen–Schmidt condensation: Tuning molecular diversity through reaction time and order and catalyst
Sign Up to like & getrecommendations! Published in 2017 at "Arabian Journal of Chemistry"
DOI: 10.1016/j.arabjc.2017.11.005
Abstract: Abstract We here report the synthesis of novel chalcone-sulfonamide compounds based on the hybridization at 2′ position and nitro substitution at the side chalcone phenyl ring followed by tandem cyclization into quinolinone derivatives and then… read more here.
Keywords: reaction time; chalcone sulfonamide; time; hybridization ... See more keywords
Chalcone and its analogs: Therapeutic and diagnostic applications in Alzheimer's disease.
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DOI: 10.1016/j.bioorg.2021.104681
Abstract: Chalcone [(E)-1,3-diphenyl-2-propene-1-one], a small molecule with α, β unsaturated carbonyl group is a precursor or component of many natural flavonoids and isoflavonoids. It is one of the privileged structures in medicinal chemistry. It possesses a… read more here.
Keywords: alzheimer disease; chemistry; chalcone analogs; therapeutic diagnostic ... See more keywords
DFT study of third-order nonlinear susceptibility of a chalcone crystal
Sign Up to like & getrecommendations! Published in 2018 at "Chemical Physics Letters"
DOI: 10.1016/j.cplett.2018.06.001
Abstract: Abstract The linear and nonlinear properties of a new chalcone derivative, (2E)-3-(3-methylphenyl)-1-(4-nitrophenyl)prop-2-en-1-one (3MPNP), have been investigated using an iterative electrostatic embedding scheme and density functional theory (DFT) methods with standard (B3LYP) and long-range corrected (CAM-B3LYP)… read more here.
Keywords: nonlinear susceptibility; third order; study third; dft study ... See more keywords