Discovery of chalcone analogues as novel NLRP3 inflammasome inhibitors with potent anti-inflammation activities.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113417
Abstract: NLRP3 inflammasome activation plays a critical role in inflammation and its related disorders. Herein we report a hit-to-lead effort resulting in the discovery of a novel and potent class of NLRP3 inflammasome inhibitors. Among these,… read more here.
Keywords: inflammasome inhibitors; analogues novel; inflammation; discovery chalcone ... See more keywords
Insights into chalcone analogues with potential as antioxidant additives in diesel–biodiesel blends
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra07300e
Abstract: Biodiesel production is one of the promising strategies to reduce diesel consumption and an important contribution to climate change. However, biodiesel stability remains a challenging problem in biofuel use in the global energy matrix. In… read more here.
Keywords: potential antioxidant; biodiesel blends; analogues potential; diesel biodiesel ... See more keywords
Tailoring the positive and negative solvatochromism for chalcone analogues to detect heterozygous protein co-aggregation.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc00545c
Abstract: It is rare for one fluorophore scaffold to harbor both positive and negative solvatochromism. Herein, we tailor chalcone analogues to achieve both positive- and negative-polarity sensitivity of fluorescence intensity. We explore two chalcones of opposite… read more here.
Keywords: aggregation; positive negative; solvatochromism; chalcone analogues ... See more keywords