Mechanistic insights into the inhibition mechanism of cysteine cathepsins by chalcone-based inhibitors—a QM cluster model approach
Sign Up to like & getrecommendations! Published in 2019 at "Structural Chemistry"
DOI: 10.1007/s11224-018-1273-3
Abstract: Cathepsins are the most abundant cysteine proteases involved in many physiological processes. The imbalance between the natural cysteine protease inhibitors and cathepsins leads to many pathological conditions such as cancer, osteoporosis, and osteoarthritis. Thus, cysteine… read more here.
Keywords: cysteine; chalcone based; cysteine cathepsins; inhibition mechanism ... See more keywords
Targeting microbial resistance: Synthesis, antibacterial evaluation, DNA binding and modeling study of new chalcone-based dithiocarbamate derivatives.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.01.001
Abstract: New dithiocarbamate chalcone-based derivatives were synthesized, their structures were elucidated using different spectroscopic techniques. They were subjected to antimicrobial screening against selected Gram negative bacteria focusing on microbial resistance. Bacterial resistance was targeted via phosphoethanolamine… read more here.
Keywords: dna; dithiocarbamate; microbial resistance; resistance ... See more keywords
Chalcone Based Homodimeric PET Agent, 11C-(Chal)2DEA-Me, for Beta Amyloid Imaging: Synthesis and Bioevaluation.
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DOI: 10.1021/acs.molpharmaceut.7b01070
Abstract: Homodimeric chalcone based 11C-PET radiotracer, 11C-(Chal)2DEA-Me, was synthesized, and binding affinity toward beta amyloid (Aβ) was evaluated. The computational studies revealed multiple binding of the tracer at the recognition sites of Aβ fibrils. The bivalent… read more here.
Keywords: chal 2dea; 11c chal; beta amyloid; chalcone based ... See more keywords
Skeletal remodeling of chalcone-based pyridinium salts to access isoindoline polycycles and their bridged derivatives
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DOI: 10.1039/d1sc05741c
Abstract: Simultaneous deconstructive ring-opening and skeletal reconstruction of an inert, aromatic pyridinium ring is of great importance in synthetic communities. However, research in this area is still in its infancy. Here, a skeletal re-modeling strategy was… read more here.
Keywords: isoindoline polycycles; pyridinium salts; pyridinium; based pyridinium ... See more keywords
Theoretical insights into the metal chelating and antimicrobial properties of the chalcone based Schiff bases
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Simulation"
DOI: 10.1080/08927022.2019.1573370
Abstract: ABSTRACT The emergence of multi-drug resistant pathogens in infectious disease conditions accentuates the need for the design of new classes of antimicrobial agents that could defeat the multidrug resistance problems. As a new class of… read more here.
Keywords: schiff bases; metal; geometry; based schiff ... See more keywords
Recent advances in chalcone-based anticancer heterocycles: A structural and molecular target perspective.
Sign Up to like & getrecommendations! Published in 2021 at "Current medicinal chemistry"
DOI: 10.2174/0929867328666210322102836
Abstract: Chalcones are an interesting class of compounds endowed with a plethora of biological activities beneficial to human health. These chemo types have continued to attract increased research attention over the years; hence, numerous natural and… read more here.
Keywords: based anticancer; recent advances; advances chalcone; anticancer ... See more keywords
Protective Effects of the Chalcone-Based Derivative AN07 on Inflammation-Associated Myotube Atrophy Induced by Lipopolysaccharide
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232112929
Abstract: Inflammation is a major cause of skeletal muscle atrophy in various diseases. 2-Hydroxy-4′-methoxychalcone (AN07) is a chalcone-based peroxisome-proliferator-activated receptor gamma (PPARγ) agonist with various effects, such as antiatherosclerosis, anti-inflammation, antioxidative stress, and neuroprotection. In this… read more here.
Keywords: inflammation; inflammation associated; myotube atrophy; chalcone based ... See more keywords