Synthesis and biological evaluation of new quinoline‐4‐carboxylic acid‐chalcone hybrids as dihydroorotate dehydrogenase inhibitors
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DOI: 10.1002/ardp.202200374
Abstract: Fourteen novel quinoline‐4‐carboxylic acid‐chalcone hybrids were obtained via Claisen–Schmidt condensation and evaluated as potential human dihydroorotate dehydrogenase (hDHODH) inhibitors. The ketone precursor 2 was synthesized by the Pfitzinger reaction and used for further derivatization at… read more here.
Keywords: carboxylic acid; acid chalcone; chalcone hybrids; dihydroorotate dehydrogenase ... See more keywords