Synthesis and biological evaluation of new quinoline‐4‐carboxylic acid‐chalcone hybrids as dihydroorotate dehydrogenase inhibitors
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DOI: 10.1002/ardp.202200374
Abstract: Fourteen novel quinoline‐4‐carboxylic acid‐chalcone hybrids were obtained via Claisen–Schmidt condensation and evaluated as potential human dihydroorotate dehydrogenase (hDHODH) inhibitors. The ketone precursor 2 was synthesized by the Pfitzinger reaction and used for further derivatization at… read more here.
Keywords: carboxylic acid; acid chalcone; chalcone hybrids; dihydroorotate dehydrogenase ... See more keywords
Design, Synthesis, and In Silico Studies of 1,2,3-Triazole-Linked Coumarin–Chalcone Hybrids as Potential Antifungal Agents
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DOI: 10.1055/a-2577-0837
Abstract: Fungal infections are a growing global health concern due to their rising incidence and increasing resistance to existing drugs. With the aim of developing new antifungal candidates, this study introduces a series of novel coumarin–chalcone… read more here.
Keywords: antifungal agents; chalcone hybrids; triazole linked; potential antifungal ... See more keywords
Novel coumarin-6-sulfonamide-chalcone hybrids as glutathione transferase P1-1 inhibitors
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DOI: 10.1371/journal.pone.0306124
Abstract: Multidrug resistance (MDR) mechanisms in cancer cells are greatly influenced by glutathione transferase P1-1 (hGSTP1-1). The use of synthetic or natural compounds as hGSTP1-1 inhibitors is considered an effective approach to overcome MDR. Nine compounds… read more here.
Keywords: chalcone hybrids; glutathione transferase; chalcone; coumarin sulfonamide ... See more keywords