Design, synthesis and evaluation of chalcones as H1N1 Neuraminidase inhibitors
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DOI: 10.1007/s00044-017-2124-2
Abstract: A series of chalcone derivatives (1a–2i) were designed based on isoliquiritigenin (the most active natural chalcone non-competitive neuraminidase (NA) inhibitor). Molecular modeling studies revealed that isoliquiritigenin and its designed analogs occupied 430-loop cavity of NA… read more here.
Keywords: h1n1 neuraminidase; design synthesis; chalcones h1n1; inhibition ... See more keywords