Pharmacophore optimization of imidazole chalcones to modulate microtubule dynamics.
Sign Up to like & getrecommendations! Published in 2022 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2022.105700
Abstract: We recently reported a new class of imidazole-based chalcones as potential antimitotic agents. In view of their promising cytotoxic activity, a comprehensive structure-activity relationship (SAR) of these compounds was undertaken focusing on four major structural… read more here.
Keywords: pharmacophore optimization; chalcones modulate; microtubule dynamics; optimization imidazole ... See more keywords