Development of an immersion challenge model for Streptococcus agalactiae in Nile tilapia (Oreochromis niloticus)
Sign Up to like & getrecommendations! Published in 2021 at "Aquaculture"
DOI: 10.1016/j.aquaculture.2020.735877
Abstract: Abstract Streptococcus agalactiae, the causative agent of streptococcosis in fish, induces significant mortality in the tilapia aquaculture. To elucidate the pathogenesis of S. agalactiae in tilapia, a simple and feasible challenge model was established in… read more here.
Keywords: immersion challenge; challenge model; tilapia; mortality ... See more keywords
Transcriptomic characterization of the human segmental endotoxin challenge model
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-51547-0
Abstract: Segmental instillation of lipopolysaccharide (LPS) by bronchoscopy safely induces transient airway inflammation in human lungs. This model enables investigation of pulmonary inflammatory mechanisms as well as pharmacodynamic analysis of investigational drugs. The aim of this… read more here.
Keywords: respiratory diseases; challenge model; model; human segmental ... See more keywords
A noninvasive BCG skin challenge model for assessing tuberculosis vaccine efficacy
Sign Up to like & getrecommendations! Published in 2024 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3002766
Abstract: We report here on the characterisation in mice of a noninvasive bacille Calmette-Guérin (BCG) skin challenge model for assessing tuberculosis (TB) vaccine efficacy. Controlled human infection models (CHIMs) are valuable tools for assessing the relevant… read more here.
Keywords: bcg; challenge model; skin challenge; challenge ... See more keywords
A new human challenge model for testing heat-stable toxin-based vaccine candidates for enterotoxigenic Escherichia coli diarrhea – dose optimization, clinical outcomes, and CD4+ T cell responses
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0007823
Abstract: Enterotoxigenic Escherichia coli (ETEC) are a common cause of diarrheal illness in young children and travelers. There is yet no licensed broadly protective vaccine against ETEC. One promising vaccine development strategy is to target strains… read more here.
Keywords: based vaccine; challenge; human challenge; vaccine ... See more keywords
The development of a dexamethasone challenge model for evaluating feed additives in sheep.
Sign Up to like & getrecommendations! Published in 2024 at "American journal of veterinary research"
DOI: 10.2460/ajvr.24.02.0035
Abstract: OBJECTIVE To develop an accessible ruminant immune challenge model for rapid in vivo assessments of feed additives. ANIMALS 60 hair-breed ram lambs. METHODS Sheep were randomly assigned to 1 of 4 treatments: treatment 1, not… read more here.
Keywords: treatment; skin induration; feed additives; challenge model ... See more keywords
Use of a Clostridioides difficile Murine Immunization and Challenge Model to Evaluate Single and Combination Vaccine Adjuvants Consisting of Alum and NKT Cell-Activating Ligands
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.818734
Abstract: Adjuvant combinations may enhance or broaden the expression of immune responses to vaccine antigens. Information on whether established Alum type adjuvants can be combined with experimental CD1d ligand adjuvants is currently lacking. In this study,… read more here.
Keywords: challenge model; alum; vaccine; combination ... See more keywords
Evaluation of the Epithelial Barrier Function and Ileal Microbiome in an Established Necrotic Enteritis Challenge Model in Broiler Chickens
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2018.00199
Abstract: Necrotic enteritis (NE) is a recognized multifactorial disease that cost annually to the poultry industry around $2 billion. However, diverse aspects related to its presentation are not completely understood, requiring further studies using known induction… read more here.
Keywords: microbiome; challenge model; necrotic enteritis; ileal ... See more keywords