Challenges in the clinical interpretation of small de novo copy number variants in neurodevelopmental disorders.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2019.05.007
Abstract: In clinical genetics, the need to discriminate between benign and pathogenic variants identified in patients with neurodevelopmental disorders is an absolute necessity. Copy number variants (CNVs) of small size can enable the identification of genes… read more here.
Keywords: copy number; challenges clinical; cnvs; number variants ... See more keywords
Challenges in the clinical education of the nursing profession in Iran: A qualitative study.
Sign Up to like & getrecommendations! Published in 2018 at "Nurse education today"
DOI: 10.1016/j.nedt.2018.04.010
Abstract: INTRODUCTION Clinical education is an important part of nurse training. It provides students with the opportunity to gain useful experience and has a key role in their professional preparation. The importance of clinical education in… read more here.
Keywords: clinical education; challenges clinical; education nursing; study ... See more keywords
Circular RNAs in hypertension: challenges and clinical promise
Sign Up to like & getrecommendations! Published in 2019 at "Hypertension Research"
DOI: 10.1038/s41440-019-0294-7
Abstract: Hypertension (HT), or high blood pressure (BP), is a chronic disease that is common among populations worldwide. The occurrence of HT is one of the leading causes of cardiovascular morbidity and mortality in adults. Although… read more here.
Keywords: promise; circular rnas; rnas hypertension; challenges clinical ... See more keywords
Challenges in the clinical development of non-D2 compounds for schizophrenia
Sign Up to like & getrecommendations! Published in 2022 at "Current Medical Research and Opinion"
DOI: 10.1080/03007995.2022.2147342
Abstract: Abstract Schizophrenia is a chronic, heterogeneous, severe psychiatric disorder characterized by a spectrum of symptomology and is associated with substantial morbidity and mortality. For the last 70 years, available treatments have shared blockade of dopamine D2… read more here.
Keywords: challenges clinical; development; non compounds; clinical development ... See more keywords
Virtual Rehabilitation with Children: Challenges for Clinical Adoption [From the Field]
Sign Up to like & getrecommendations! Published in 2017 at "IEEE Pulse"
DOI: 10.1109/mpul.2017.2750858
Abstract: Virtual, augmented, and mixed reality environments are increasingly being developed and used to address functional rehabilitation goals related to physical, cognitive, social, and psychological impairments. For example, a child with an acquired brain injury may… read more here.
Keywords: children challenges; challenges clinical; virtual rehabilitation; rehabilitation children ... See more keywords
Bioprinting of exosomes: Prospects and challenges for clinical applications
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Bioprinting"
DOI: 10.18063/ijb.690
Abstract: 453Three-dimensional bioprinting (3DBP) is an additive manufacturing technique that has emerged as a promising strategy for the fabrication of scaffolds, which can successfully recapitulate the architectural, biochemical, and physical cues of target tissues. More importantly,… read more here.
Keywords: cell; challenges clinical; exos; exosomes prospects ... See more keywords
Challenges in the clinical understanding of genetic testing in birth defects and pediatric diseases
Sign Up to like & getrecommendations! Published in 2023 at "Translational Pediatrics"
DOI: 10.21037/tp-23-54
Abstract: Advances in prenatal/neonatal genetic screening practices and next generation sequencing (NGS) technologies have made the detection of molecular causes of pediatric diseases increasingly more affordable, accessible, and rapid in return of results. In the past,… read more here.
Keywords: neonatal care; challenges clinical; pediatric diseases; genetic testing ... See more keywords
The Necessity and Challenges of Clinical Research Involving Children
Sign Up to like & getrecommendations! Published in 2019 at "Bangladesh Journal of Medical Science"
DOI: 10.3329/bjms.v18i3.41610
Abstract: Abstract not available Bangladesh Journal of Medical Science Vol.18(3) 2019 p.451-452 read more here.
Keywords: involving children; necessity challenges; clinical research; challenges clinical ... See more keywords
Challenges for Clinical Development of Vaccines for Prevention of Hospital-Acquired Bacterial Infections
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.01755
Abstract: Increasing antibiotic resistance in bacteria causing endogenous infections has entailed a need for innovative approaches to therapy and prophylaxis of these infections and raised a new interest in vaccines for prevention of colonization and infection… read more here.
Keywords: challenges clinical; clinical development; infection; vaccines prevention ... See more keywords
Inhibition of galectins in cancer: Biological challenges for their clinical application
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1104625
Abstract: Galectins play relevant roles in tumor development, progression and metastasis. Accordingly, galectins are certainly enticing targets for medical intervention in cancer. To date, however, clinical trials based on galectin inhibitors reported inconclusive results. This review… read more here.
Keywords: biological challenges; challenges clinical; cancer biological; galectins cancer ... See more keywords
Challenges for Clinical Drug Development in Pulmonary Fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.823085
Abstract: Pulmonary fibrosis is a pathologic process associated with scarring of the lung interstitium. Interstitial lung diseases (ILDs) encompass a large and heterogenous group of disorders, a number of which are characterized by progressive pulmonary fibrosis… read more here.
Keywords: challenges clinical; development; pulmonary fibrosis; clinical drug ... See more keywords