Opportunities and Challenges in the Discovery of Allosteric Modulators of GPCRs.
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DOI: 10.1007/978-1-4939-7465-8_13
Abstract: From the pharmacological point of view, allosteric modulators may present numerous advantages over orthosteric ligands. Growing availability of novel tools and experimental data provides a tempting opportunity to apply computational methods to improve known modulators… read more here.
Keywords: modulators gpcrs; challenges discovery; allosteric modulators; opportunities challenges ... See more keywords
Challenges with the discovery of RNA-based therapeutics for flaviviruses
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DOI: 10.1080/17460441.2023.2195164
Abstract: ABSTRACT Introduction Flaviviruses are emerging or reemerging pathogens that have caused several outbreaks throughout the world and pose serious threats on human health and economic development. RNA-based therapeutics are developing rapidly, and hold promise in… read more here.
Keywords: rna based; challenges discovery; based therapeutics; therapeutics flaviviruses ... See more keywords
Novel Approaches and Challenges of Discovery of Exosite Modulators of a Disintegrin and Metalloprotease 10
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DOI: 10.3389/fmolb.2020.00075
Abstract: A disintegrin and metaproteinase 10 is an important target for multiple therapeutic areas, however, despite drug discovery efforts by both industry and academia no compounds have reached the clinic so far. The lack of enzyme… read more here.
Keywords: novel approaches; challenges discovery; approaches challenges; discovery exosite ... See more keywords