Systemic therapy in metastatic renal cell carcinoma: Emerging challenges in therapeutic choice.
Sign Up to like & getrecommendations! Published in 2020 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2020.102971
Abstract: The treatment landscape for metastatic renal cell carcinoma (mRCC) has undergone a substantial evolution in the past decade, with a dramatic increase in the number of available systemic therapies. Although this offers promise for improved… read more here.
Keywords: renal cell; cell carcinoma; challenges therapeutic; metastatic renal ... See more keywords
siRNA: Mechanism of action, challenges, and therapeutic approaches.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174178
Abstract: Owing to specific and compelling gene silencing, RNA interference (RNAi) is expected to become an essential approach in treating a variety of infectious, hemato-oncological, cardiovascular, and neurodegenerative conditions. The mechanism of action of small interfering… read more here.
Keywords: sirna mechanism; action challenges; challenges therapeutic; mechanism action ... See more keywords
Advances and challenges in therapeutic monoclonal antibodies drug development
Sign Up to like & getrecommendations! Published in 2018 at "Brazilian Journal of Pharmaceutical Sciences"
DOI: 10.1590/s2175-97902018000001007
Abstract: The use of serum containing polyclonal antibodies from animals immunized with toxins marked the beginning of the application of antibody-based therapy in late nineteenth century. Advances in basic research led to the development of the… read more here.
Keywords: monoclonal antibodies; therapeutic monoclonal; drug; challenges therapeutic ... See more keywords
Alzheimer’s Disease: Challenges and a Therapeutic Opportunity to Treat It with a Neurotrophic Compound
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12101409
Abstract: Alzheimer’s disease (AD) is a progressive neurodegenerative disease with an insidious onset and multifactorial nature. A deficit in neurogenesis and synaptic plasticity are considered the early pathological features associated with neurofibrillary tau and amyloid β… read more here.
Keywords: neurotrophic factors; disease challenges; compound; disease ... See more keywords
Molecular Basis, Diagnostic Challenges and Therapeutic Approaches of Bartter and Gitelman Syndromes: A Primer for Clinicians
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms222111414
Abstract: Gitelman and Bartter syndromes are rare inherited diseases that belong to the category of renal tubulopathies. The genes associated with these pathologies encode electrolyte transport proteins located in the nephron, particularly in the Distal Convoluted… read more here.
Keywords: basis diagnostic; molecular basis; diagnostic challenges; therapeutic approaches ... See more keywords
The Challenges and Therapeutic Prospects in Eye Disease
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm13060930
Abstract: A number of key insights into eye disease have been revealed in the past decade, which has resulted in the development of novel, effective, targeted therapies such as teprotumumab for the treatment of thyroid eye… read more here.
Keywords: challenges therapeutic; therapeutic prospects; prospects eye; eye ... See more keywords