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Challenging clinically unresponsive medullary thyroid cancer: Discovery and pharmacological activity of novel RET inhibitors.

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0 Published in 2018 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2018.02.080

Abstract: It is now known that "gain of function" mutations of RET (REarranged during Transfection) kinase are specific and key oncogenic events in the onset of thyroid gland cancers such as the Medullary Thyroid Carcinoma (MTC).… read more here.

Keywords: medullary thyroid; challenging clinically; clinically unresponsive; ret inhibitors ... See more keywords