Challenging the Paradigm: EGFR wild-type benefit from an EGFR inhibitor in NSCLC
Sign Up to like & getrecommendations! Published in 2017 at "Cancer treatment and research"
DOI: 10.1016/j.ctarc.2017.02.005
Abstract: Erlotinib and gefitinib are first generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI). Afatinib is a second generation pan-Her EGFR TKI. All three TKIs have demonstrated superiority to chemotherapy in the first line… read more here.
Keywords: egfr mutation; egfr wild; type benefit; paradigm egfr ... See more keywords
The challenging paradigm of interrelated energy systems towards a more sustainable future
Sign Up to like & getrecommendations! Published in 2018 at "Renewable and Sustainable Energy Reviews"
DOI: 10.1016/j.rser.2018.07.023
Abstract: This paper brings together several contemporary topics in energy systems aiming to provide a literature review based reflection on how several interrelated energy systems can contribute together to a more sustainable world. Some directions are… read more here.
Keywords: energy systems; energy; interrelated energy; systems towards ... See more keywords
Matrix Metalloproteinases: A challenging paradigm of cancer management.
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2017.11.008
Abstract: Matrix metalloproteinases (MMPs) are members of zinc-dependent endopeptidases implicated in a variety of physiological and pathological processes. Over the decades, MMPs have been studied for their role in cancer progression, migration, and metastasis. As a… read more here.
Keywords: paradigm cancer; metalloproteinases challenging; cancer; challenging paradigm ... See more keywords
Challenging the Paradigm of Persistent Air Leak: Are We Prolonging the Problem?
Sign Up to like & getrecommendations! Published in 2022 at "American journal of respiratory and critical care medicine"
DOI: 10.1164/rccm.202109-2149pp
Abstract: You are managing a patient with a spontaneous pneumothorax and a chest drain in situ, with evidence of ongoing air leak on the fifth day post insertion. You pause to consider this case of persistent… read more here.
Keywords: paradigm persistent; air leak; persistent air; challenging paradigm ... See more keywords
Challenging the paradigm
Sign Up to like & getrecommendations! Published in 2022 at "Breathe"
DOI: 10.1183/20734735.0148-2021
Abstract: I read with interest the review by Bush and Pavord [1] regarding the suggestion that we should abandon “umbrella” diagnoses and rather we should address “treatable traits” when looking after patients with airways disease. Unfortunately,… read more here.
Keywords: challenging paradigm; paradigm;
Reply to: Challenging the paradigm
Sign Up to like & getrecommendations! Published in 2022 at "Breathe"
DOI: 10.1183/20734735.0174-2021
Abstract: We thank M.L. Everard for his interest in our article [1] and thank the Editors for giving us the opportunity to respond. Space constraints precluded us describing the detailed management of extrapulmonary treatable traits, hence… read more here.
Keywords: challenging paradigm; reply challenging;