Factors influencing efficacy endpoints in clinical trials for new oral medicinal treatments for overactive bladder: a systematic literature review and meta-analysis
Sign Up to like & getrecommendations! Published in 2018 at "International Urology and Nephrology"
DOI: 10.1007/s11255-018-1869-y
Abstract: PurposeOveractive bladder (OAB) is a symptom-based disease; therefore, clinical trials to evaluate treatments for OAB employ a range of efficacy endpoints. Since factors that influence efficacy endpoints can affect trial outcomes, their identification could aid… read more here.
Keywords: change baseline; efficacy endpoints; clinical trials; factors influencing ... See more keywords
Tropomyosin-related Kinase A (TrkA) Inhibition for the Treatment of Painful Knee Osteoarthritis: Results From a Randomized Controlled Phase 2a Trial.
Sign Up to like & getrecommendations! Published in 2019 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2019.05.029
Abstract: OBJECTIVE To investigate the TrkA inhibitor, ASP7962, for treatment of painful knee osteoarthritis. DESIGN Phase 2a, double-blind, placebo- and naproxen-controlled, double-dummy, parallel-group study. Adults with knee osteoarthritis were randomized (2:2:1) to ASP7962 (100 mg), placebo,… read more here.
Keywords: painful knee; treatment; change baseline; knee osteoarthritis ... See more keywords
Re: Estimating the Causal Effect of an Exposure on Change From Baseline Using Directed Acyclic Graphs and Path Analysis.
Sign Up to like & getrecommendations! Published in 2017 at "Epidemiology"
DOI: 10.1097/ede.0000000000000620
Abstract: © 2017 Wolters Kluwer Health, Inc. All rights reserved. www.epidem.com | e27 The authors report no conflicts of interest. This study was supported in part by the UW NIEHS sponsored Biostatistics, Epidemiologic and Bioinformatic Training… read more here.
Keywords: baseline using; exposure change; change baseline; causal effect ... See more keywords
Effect of milk protein intake and casein-to-whey ratio in breakfast meals on postprandial glucose, satiety ratings, and subsequent meal intake.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of dairy science"
DOI: 10.3168/jds.2018-14419
Abstract: Whey and casein proteins differentially affect postprandial blood glucose and satiety mechanisms, with relevance for type 2 diabetes and obesity. Therefore, the purpose of this work was to investigate the effect of the casein-to-whey protein… read more here.
Keywords: change baseline; effect; blood; blood glucose ... See more keywords