Multistep changes in amyloid structure induced by cross-seeding on a rugged energy landscape.
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical journal"
DOI: 10.1016/j.bpj.2020.12.005
Abstract: Amyloid fibrils are aberrant protein aggregates associated with various amyloidoses and neurodegenerative diseases. It is recently indicated that structural diversity of amyloid fibrils often results in different pathological phenotypes including cytotoxicity and infectivity. The diverse… read more here.
Keywords: changes amyloid; structure; amyloid fibrils; cross seeding ... See more keywords
The age-specific pathological changes of β-amyloid plaques in the cortex and hippocampus of APP/PS1 transgenic AD mice
Sign Up to like & getrecommendations! Published in 2022 at "Neurological Research"
DOI: 10.1080/01616412.2022.2112368
Abstract: ABSTRACT Objective Numerous pathological variations and complex interactions are involved in the long period prior to cognitive decline in brains with Alzheimer’s disease (AD). Thus, elucidation of the pathological disorders can facilitate early AD diagnosis.… read more here.
Keywords: changes amyloid; age; cortex hippocampus; mice ... See more keywords