When Two Become One: Conformational Changes in FXR/RXR Heterodimers Bound to Steroidal Antagonists
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DOI: 10.1002/cmdc.202200556
Abstract: Farnesoid X receptor (FXR) is a nuclear receptor with an essential role in regulating bile acid synthesis and cholesterol homeostasis. FXR activation by agonists is explained by an αAF‐2‐trapping mechanism; however, antagonism mechanisms are diverse.… read more here.
Keywords: changes fxr; two become; conformational changes; fxr rxr ... See more keywords