Can changes in 3D genome architecture create new regulatory landscapes that contribute to phenotypic evolution?
Sign Up to like & getrecommendations! Published in 2022 at "Essays in biochemistry"
DOI: 10.1042/ebc20220057
Abstract: Animal genomes are compartmentalized into insulated regulatory units named topology-associated domains (TADs). TADs insulate gene promoters from enhancers that occupy neighboring TADs. Chromosomal rearrangements that disrupt TAD structure can generate new regulatory interactions between enhancers… read more here.
Keywords: tad structure; evolution; changes genome; gene ... See more keywords
Cytokine Pathways in Cardiac Dysfunction following Burn Injury and Changes in Genome Expression
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12111876
Abstract: In 2016, an estimated 486,000 individuals sustained burn injuries requiring medical attention. Severe burn injuries lead to a persistent, hyperinflammatory response that may last up to 2 years. The persistent release of inflammatory mediators contributes… read more here.
Keywords: burn injuries; genome expression; dysfunction; changes genome ... See more keywords