Investigation of the Captopril–Insulin Interaction by Mass Spectrometry and Computational Approaches Reveals that Captopril Induces Structural Changes in Insulin
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DOI: 10.1021/acsomega.2c00660
Abstract: Post-translational modifications remarkably regulate proteins’ biological function. Small molecules such as reactive thiols, metabolites, and drugs may covalently modify the proteins and cause structural changes. This study reports the covalent modification and noncovalent interaction of… read more here.
Keywords: mass spectrometric; captopril; changes insulin; structural changes ... See more keywords
Genomics and transcriptomics landscapes associated to changes in insulin sensitivity in response to endurance exercise training
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DOI: 10.1038/s41598-021-98792-1
Abstract: Despite good adherence to supervised endurance exercise training (EET), some individuals experience no or little improvement in peripheral insulin sensitivity. The genetic and molecular mechanisms underlying this phenomenon are currently not understood. By investigating genome-wide… read more here.
Keywords: changes insulin; endurance exercise; insulin sensitivity; exercise ... See more keywords
Impairment in insulin secretion without changes in insulin resistance explains hyperglycemia in patients with acromegaly treated with pasireotide LAR
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DOI: 10.1530/ec-22-0296
Abstract: Objective Pasireotide is a second-generation somatostatin receptor ligand (SRL) used for treating acromegaly. Its clinical use is limited by adverse effects on glucose homeostasis. The aim of this study was to evaluate longitudinal changes in… read more here.
Keywords: changes insulin; insulin sensitivity; insulin secretion; insulin ... See more keywords