Astrocytic Changes in Mitochondrial Oxidative Phosphorylation Protein Levels in Parkinson's Disease
Sign Up to like & getrecommendations! Published in 2021 at "Movement Disorders"
DOI: 10.1002/mds.28849
Abstract: Mitochondrial dysfunction within neurons, particularly those of the substantia nigra, has been well characterized in Parkinson's disease and is considered to be related to the pathogenesis of this disorder. Dysfunction within this important organelle has… read more here.
Keywords: oxidative phosphorylation; astrocytic changes; mitochondrial oxidative; disease ... See more keywords
Changes in the mitochondrial function and in the efficiency of energy transfer pathways during cardiomyocyte aging
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-3005-1
Abstract: The role of mitochondria in alterations that take place in the muscle cell during healthy aging is a matter of debate during recent years. Most of the studies in bioenergetics have a focus on the… read more here.
Keywords: energy transfer; energy; changes mitochondrial; mitochondrial function ... See more keywords
Hepatic encephalopathy changes mitochondrial dynamics and autophagy in the substantia nigra
Sign Up to like & getrecommendations! Published in 2018 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-018-0275-6
Abstract: Hepatic encephalopathy (HE) has been reported in more than 40% of patients with cirrhosis in clinical practice. HE changes mitochondrial dysfunction. Mitochondrial dynamics and autophagy are important for maintaining and removing damaged mitochondria. We used… read more here.
Keywords: autophagy substantia; changes mitochondrial; substantia nigra; hepatic encephalopathy ... See more keywords
New N-9- sulfonylpurine derivatives induce changes in mitochondrial function and ROS accumulation in carcinoma and leukemia cells in vitro
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.05.041
Abstract: Our recent studies showed significant antiproliferative capacity of newly synthesized N-9-sulfonylpyrimidine derivatives on human carcinoma, lymphoma, and leukemia cells. These derivatives behave as antimetabolites exploiting cellular metabolism to induce cytotoxicity in treated tumors’ cells [1-3].… read more here.
Keywords: sulfonylpurine; leukemia cells; ros accumulation; changes mitochondrial ... See more keywords
Conformational changes in mitochondrial complex I of the thermophilic eukaryote Chaetomium thermophilum
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1101/2022.05.13.491814
Abstract: Mitochondrial complex I is a redox-driven proton pump that generates proton-motive force across the inner mitochondrial membrane, powering oxidative phosphorylation and ATP synthesis in eukaryotes. We report the structure of complex I from the thermophilic… read more here.
Keywords: mitochondrial complex; conformational changes; chaetomium thermophilum; complex thermophilic ... See more keywords
Detection of changes in mitochondrial hydrogen sulfide in vivo in the fish model Poecilia mexicana (Poeciliidae)
Sign Up to like & getrecommendations! Published in 2019 at "Biology Open"
DOI: 10.1242/bio.041467
Abstract: ABSTRACT In this paper, we outline the use of a mitochondria-targeted ratiometric mass spectrometry probe, MitoA, to detect in vivo changes in mitochondrial hydrogen sulfide (H2S) in Poecilia mexicana (family Poeciliidae). MitoA is introduced via… read more here.
Keywords: mitochondrial hydrogen; poecilia mexicana; mitoa; changes mitochondrial ... See more keywords
Methods to Evaluate Changes in Mitochondrial Structure and Function in Cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15092564
Abstract: Simple Summary Mitochondria, which play crucial roles in energy production and in maintaining cellular homeostasis, are potential therapeutic targets in a variety of diseases including cancer. This review discusses methods to evaluate the structural and… read more here.
Keywords: function; changes mitochondrial; structure function; mitochondrial structure ... See more keywords
Changes in Metabolism and Mitochondrial Bioenergetics during Polyethylene-Induced Osteoclastogenesis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158331
Abstract: Changes in mitochondrial bioenergetics are believed to take place during osteoclastogenesis. This study aims to assess changes in mitochondrial bioenergetics and reactive oxygen species (ROS) levels during polyethylene (PE)-induced osteoclastogenesis in vitro. For this purpose,… read more here.
Keywords: polyethylene induced; mitochondrial bioenergetics; osteoclastogenesis; induced osteoclastogenesis ... See more keywords
Nitric Oxide Donor NOC-18-Induced Changes of Mitochondrial Phosphoproteome in Rat Cardiac Ischemia Model
Sign Up to like & getrecommendations! Published in 2019 at "Medicina"
DOI: 10.3390/medicina55100631
Abstract: Background and objective: Nitric oxide (NO) is known to exert cardioprotective effects against heart ischemic damage and may be involved in ischemic pre- and postconditioning. NO-triggered cardioprotective mechanisms are not well understood but may involve… read more here.
Keywords: donor noc; changes mitochondrial; mitochondrial phosphoproteome; ischemia ... See more keywords
Changes in mitochondrial function during EMT induced by TGFβ-1 in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncology Letters"
DOI: 10.3892/ol.2017.5613
Abstract: Mitochondrial dysfunction is linked to cancer. Differences in the number, morphology and function of mitochondria have been observed between normal cells and cancer cells. However, changes in mitochondrial function during epithelial-mesenchymal transition (EMT) in pancreatic… read more here.
Keywords: changes mitochondrial; mitochondrial function; pancreatic cancer; mitochondrial dysfunction ... See more keywords