Elucidating molecular mechanisms of functional conformational changes of proteins via Markov state models.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2020.10.005
Abstract: Functional conformational changes of proteins can facilitate numerous biological events in cells. The Markov state model (MSM) built from molecular dynamics simulations provide a powerful approach to study them. We here introduce a protocol that… read more here.
Keywords: mechanisms functional; markov state; functional conformational; changes proteins ... See more keywords
A Linear Discriminant Analysis Model Based on the Changes of 7 Proteins in Plasma Predicts Response to Anlotinib Therapy in Advanced Non-Small Cell Lung Cancer Patients
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DOI: 10.3389/fonc.2021.756902
Abstract: Background Anlotinib is a multi-targeted tyrosine kinase inhibitor mainly targeting angiogenesis signaling. The predictive marker of anlotinib’s efficacy remains elusive. This study was designed to explore the predictive marker of anlotinib in non-small cell lung… read more here.
Keywords: analysis; model based; non small; model ... See more keywords
Structural changes of proteins in liver cirrhosis and consequential changes in their function
Sign Up to like & getrecommendations! Published in 2022 at "World Journal of Gastroenterology"
DOI: 10.3748/wjg.v28.i29.3780
Abstract: The liver is the site of synthesis of the majority of circulating proteins. Besides initial polypeptide synthesis, sophisticated machinery is involved in the further processing of proteins by removing parts of them and/or adding functional… read more here.
Keywords: liver cirrhosis; changes proteins; changes function; proteins liver ... See more keywords