SCISSOR: a framework for identifying structural changes in RNA transcripts
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-020-20593-3
Abstract: High-throughput sequencing protocols such as RNA-seq have made it possible to interrogate the sequence, structure and abundance of RNA transcripts at higher resolution than previous microarray and other molecular techniques. While many computational tools have… read more here.
Keywords: framework; rna seq; changes rna; rna transcripts ... See more keywords
Ribosome-dependent conformational flexibility changes and RNA dynamics of IRES domains revealed by differential SHAPE
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-23845-x
Abstract: Internal ribosome entry site (IRES) elements are RNA regions that recruit the translation machinery internally. Here we investigated the conformational changes and RNA dynamics of a picornavirus IRES upon incubation with distinct ribosomal fractions. Differential… read more here.
Keywords: rna dynamics; differential shape; ribosome dependent; flexibility ... See more keywords
MutaRNA: analysis and visualization of mutation-induced changes in RNA structure
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa331
Abstract: Abstract RNA molecules fold into complex structures as a result of intramolecular interactions between their nucleotides. The function of many non-coding RNAs and some cis-regulatory elements of messenger RNAs highly depends on their fold. Single-nucleotide… read more here.
Keywords: induced changes; mutation induced; structure; changes rna ... See more keywords