Niclosamide affects intracellular TDP-43 distribution in motor neurons, activates mitophagy, and attenuates morphological changes under stress.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of bioscience and bioengineering"
DOI: 10.1016/j.jbiosc.2021.06.015
Abstract: Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron loss in the brain and spinal cord; however, its etiology is unknown, and no curative treatment exists. TAR DNA-binding protein 43 (TDP-43), encoded by TARDBP,… read more here.
Keywords: morphological changes; tdp; motor neurons; changes stress ... See more keywords
Gonadal steroid hormone receptors in the medial amygdala contribute to experience-dependent changes in stress vulnerability
Sign Up to like & getrecommendations! Published in 2021 at "Psychoneuroendocrinology"
DOI: 10.1016/j.psyneuen.2021.105249
Abstract: Social experience can generate neural plasticity that changes how individuals respond to stress. Winning aggressive encounters alters how animals respond to future challenges and leads to increased plasma testosterone concentrations and androgen receptor (AR) expression… read more here.
Keywords: social defeat; dependent changes; changes stress; medial amygdala ... See more keywords